Literature DB >> 12062452

Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion.

Yan Chen1, Branka Dabovic, Justin P Annes, Daniel B Rifkin.   

Abstract

Latent transforming growth factor-beta (TGF-beta) binding protein (LTBP)-1, which is easily secreted, has been shown to enhance the secretion of TGF-beta. Here we show that another member of the LTBP family, LTBP-3, is not secreted by several cell types, but secretion occurs after coexpression with TGF-beta. The secretion of LTBP-3 requires complexing of LTBP-3 with Cys33 of the TGF-beta propeptide.

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Year:  2002        PMID： 12062452     DOI： 10.1016/s0014-5793(02)02648-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  24 in total

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Review 2.  Genetics of Thoracic and Abdominal Aortic Diseases.

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Review 4.  Latent TGF-β-binding proteins.

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7.  Control of lung development by latent TGF-β binding proteins.

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Review 9.  LTBPs in biology and medicine: LTBP diseases.

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10.  Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin.

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