Literature DB >> 29217273

LTBPs in biology and medicine: LTBP diseases.

Daniel B Rifkin1, William J Rifkin2, Lior Zilberberg3.   

Abstract

The latent transforming growth factor (TGF) β binding proteins (LTBP) are crucial mediators of TGFβ function, as they control growth factor secretion, matrix deposition, presentation and activation. Deficiencies in specific LTBP isoforms yield discrete phenotypes representing defects in bone, lung and cardiovascular development mediated by loss of TGFβ signaling. Additional phenotypes represent loss of unique TGFβ-independent features of LTBP effects on elastogenesis and microfibril assembly. Thus, the LTBPs act as sensors for the regulation of both growth factor activity and matrix function.
Copyright © 2018 International Society of Matrix Biology. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Aneurysm; Elastin maturation; Fibrillin; Latent TGFβ binding proteins; Marfan syndrome; TGFβ; TGFβ activation

Mesh：

Substances：

Year:  2017        PMID： 29217273      PMCID： PMC5988920          DOI： 10.1016/j.matbio.2017.11.014

Source DB:  PubMed          Journal:  Matrix Biol        ISSN： 0945-053X            Impact factor:   11.583


  84 in total

1.  Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.

Authors:  J Saharinen; J Keski-Oja
Journal:  Mol Biol Cell       Date:  2000-08       Impact factor: 4.138

Review 2.  The latent transforming growth factor beta binding protein (LTBP) family.

Authors:  R Oklü; R Hesketh
Journal:  Biochem J       Date:  2000-12-15       Impact factor: 3.857

3.  Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes.

Authors:  Yan Chen; Tariq Ali; Vesna Todorovic; Joanne M O'leary; A Kristina Downing; Daniel B Rifkin
Journal:  J Mol Biol       Date:  2005-01-07       Impact factor: 5.469

4.  Abrogation of both short and long forms of latent transforming growth factor-β binding protein-1 causes defective cardiovascular development and is perinatally lethal.

Authors:  Masahito Horiguchi; Vesna Todorovic; Krassimira Hadjiolova; Ralf Weiskirchen; Daniel B Rifkin
Journal:  Matrix Biol       Date:  2015-03-21       Impact factor: 11.583

5.  Fibronectin and heparin binding domains of latent TGF-beta binding protein (LTBP)-4 mediate matrix targeting and cell adhesion.

Authors:  Anna K Kantola; Jorma Keski-Oja; Katri Koli
Journal:  Exp Cell Res       Date:  2008-05-29       Impact factor: 3.905

6.  Matrix association of latent TGF-beta binding protein-2 (LTBP-2) is dependent on fibrillin-1.

Authors:  Piia Vehviläinen; Marko Hyytiäinen; Jorma Keski-Oja
Journal:  J Cell Physiol       Date:  2009-12       Impact factor: 6.384

7.  Novel non-TGF-beta-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-beta deposition.

Authors:  K Koli; J Saharinen; M Kärkkäinen; J Keski-Oja
Journal:  J Cell Sci       Date:  2001-08       Impact factor: 5.285

8.  Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability.

Authors:  Branka Dabovic; Yan Chen; Cristina Colarossi; Hiroto Obata; Laura Zambuto; Mary Ann Perle; Daniel B Rifkin
Journal:  J Cell Biol       Date:  2002-01-14       Impact factor: 10.539

9.  Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart.

Authors:  Y Nakajima; K Miyazono; M Kato; M Takase; T Yamagishi; H Nakamura
Journal:  J Cell Biol       Date:  1997-01-13       Impact factor: 10.539

10.  Latent TGF-β binding protein 2 and 4 have essential overlapping functions in microfibril development.

Authors:  Yusuke Fujikawa; Hideyuki Yoshida; Tadashi Inoue; Tetsuya Ohbayashi; Kazuo Noda; Harald von Melchner; Toshiji Iwasaka; Ichiro Shiojima; Tomoya O Akama; Tomoyuki Nakamura
Journal:  Sci Rep       Date:  2017-03-02       Impact factor: 4.379
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  24 in total

1.  Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers.

Authors:  Y Shi; W Jones; W Beatty; Q Tan; R P Mecham; H Kumra; D P Reinhardt; M A Gibson; M A Reilly; J Rodriguez; S Bassnett
Journal:  Matrix Biol       Date:  2020-10-09       Impact factor: 11.583

Review 2.  The ELAV family of RNA-binding proteins in synaptic plasticity and long-term memory.

Authors:  Anastasios A Mirisis; Thomas J Carew
Journal:  Neurobiol Learn Mem       Date:  2019-04-15       Impact factor: 2.877

3.  Collagen XII Regulates Corneal Stromal Structure by Modulating Transforming Growth Factor-β Activity.

Authors:  Mei Sun; Elena Koudouna; Devon Cogswell; Marcel Y Avila; Manuel Koch; Edgar M Espana
Journal:  Am J Pathol       Date:  2021-11-11       Impact factor: 4.307

4.  eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-induced Lung Fibrosis.

Authors:  Alexander N Garcia; Nancy G Casanova; Carrie L Kempf; Tadeo Bermudez; Daniel G Valera; Jin H Song; Xiaoguang Sun; Hua Cai; Liliana Moreno-Vinasco; Taylor Gregory; Radu C Oita; Vivian Reyes Hernon; Sara M Camp; Claude Rogers; Espoir M Kyubwa; Naresh Menon; James Axtelle; Jay Rappaport; Christian Bime; Saad Sammani; Anne E Cress; Joe G N Garcia
Journal:  Am J Respir Cell Mol Biol       Date:  2022-05       Impact factor: 7.748

5.  Fibronectin has multifunctional roles in posterior capsular opacification (PCO).

Authors:  Mahbubul H Shihan; Mallika Kanwar; Yan Wang; Erin E Jackson; Adam P Faranda; Melinda K Duncan
Journal:  Matrix Biol       Date:  2020-03-12       Impact factor: 11.583

6.  BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics.

Authors:  Christian Hiepen; Jerome Jatzlau; Susanne Hildebrandt; Branka Kampfrath; Melis Goktas; Arunima Murgai; Jose Luis Cuellar Camacho; Rainer Haag; Clemens Ruppert; Gerhard Sengle; Elisabetta Ada Cavalcanti-Adam; Kerstin G Blank; Petra Knaus
Journal:  PLoS Biol       Date:  2019-12-11       Impact factor: 8.029

7.  Regional heterogeneity in determinants of atrial matrix remodeling and association with atrial fibrillation vulnerability postmyocardial infarction.

Authors:  Mitchel R Stacy; Ben A Lin; Stephanie L Thorn; David C Lobb; Mark W Maxfield; Craig Novack; Kia N Zellars; Lisa Freeburg; Joseph G Akar; Albert J Sinusas; Francis G Spinale
Journal:  Heart Rhythm       Date:  2022-01-21       Impact factor: 6.779

8.  Proteomic discovery of substrates of the cardiovascular protease ADAMTS7.

Authors:  Alain Colige; Christine Monseur; James T B Crawley; Salvatore Santamaria; Rens de Groot
Journal:  J Biol Chem       Date:  2019-03-29       Impact factor: 5.157

Review 9.  Reevaluation of Pluripotent Cytokine TGF-β3 in Immunity.

Authors:  Toshihiko Komai; Tomohisa Okamura; Mariko Inoue; Kazuhiko Yamamoto; Keishi Fujio
Journal:  Int J Mol Sci       Date:  2018-08-01       Impact factor: 5.923

Review 10.  Elastin in pulmonary pathology: relevance in tumours with a lepidic or papillary appearance. A comprehensive understanding from a morphological viewpoint.

Authors:  Erik Thunnissen; Noriko Motoi; Yuko Minami; Daisuke Matsubara; Wim Timens; Yukio Nakatani; Yuichi Ishikawa; Ximena Baez-Navarro; Teodora Radonic; Hans Blaauwgeers; Alain C Borczuk; Masayuki Noguchi
Journal:  Histopathology       Date:  2021-09-23       Impact factor: 7.778
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