| Literature DB >> 12062421 |
Tomoyasu Sugiyama1, Shizuko Ishii, Jun ichi Yamamoto, Ryotaro Irie, Kaoru Saito, Tetsuji Otuki, Ai Wakamatsu, Yuzuru Suzuki, Yuri Hio, Toshio Ota, Tetsuo Nishikawa, Sumio Sugano, Yasuhiko Masuho, Takao Isogai.
Abstract
Gene expression of synoviocytes stimulated with tumor necrosis factor-alpha (TNFalpha) was studied by macroarray analysis to elucidate the cellular response and identify new biological functions of known and unknown genes. 10035 cDNA clones were used to make cDNA macroarrays of representative genes. Synoviocytes expressed large amounts of fibronectin and collagen mRNA. Statistical analysis of the macroarray data revealed 26 genes, including six new genes, which underwent significant alteration of gene expression in response to TNFalpha stimulation. These findings suggest that the synoviocyte response to TNFalpha stimulation forms the basis of development of various aspects of the pathophysiology of rheumatoid arthritis.Entities:
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Year: 2002 PMID： 12062421 DOI： 10.1016/s0014-5793(02)02588-7
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124