Literature DB >> 12057648

Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species.

Hakan Göker1, Canan Kuş, David W Boykin, Sulhiye Yildiz, Nurten Altanlar.   

Abstract

New 2-substituted-phenyl-1H-benzimidazole-5-carboxylic acids (35, 38), ethyl-5-carboxylate (36), -5-carboxamides (37, 39),-5-carboxaldehyde (42), -5-chloro (40), -5-trifluoromethyl (41), and -5-carbonitriles (44-53, 55-67), -6-carbonitrile (54) were prepared and evaluated in vitro against Candida species. The cyano substituted compounds 53, 57, 58 and 61 exhibited the greatest activity with MIC values of 3.12 microg/mL, values similar to that of fluconazole.

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Year:  2002        PMID： 12057648     DOI： 10.1016/s0968-0896(02)00103-7

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  20 in total

1.  Synthesis, characterization, DNA binding and cleavage studies of mixed-ligand Cu(II) complexes of 2,6-bis(benzimidazol-2-yl)pyridine.

Authors:  M Sunita; M Padmaja; B Anupama; C Gyana Kumari
Journal:  J Fluoresc       Date:  2012-05       Impact factor: 2.217

2.  QSAR of heterocyclic antifungal agents by flip regression.

Authors:  Omar Deeb; Brian W Clare
Journal:  J Comput Aided Mol Des       Date:  2008-06-24       Impact factor: 3.686

3.  Linear and nonlinear modeling of antifungal activity of some heterocyclic ring derivatives using multiple linear regression and Bayesian-regularized neural networks.

Authors:  Julio Caballero; Michael Fernández
Journal:  J Mol Model       Date:  2005-10-21       Impact factor: 1.810

4.  Applications of ortho-phenylisonitrile and ortho-N-Boc aniline for the two-step preparation of novel bis-heterocyclic chemotypes.

Authors:  Zhigang Xu; Arthur Y Shaw; Gary S Nichol; Alexandra P Cappelli; Christopher Hulme
Journal:  Mol Divers       Date:  2012-05-24       Impact factor: 2.943

5.  Synthesis of 2-(N-Benzylpyrrolyl)-benzimidazoles Using Polyphosphoric Acid Prompted Cyclocondensation.

Authors:  Bereket Mochona; Laine Le; Madhavi Gangapuram; Nelly Mateeva; Tiffany Ardley; Kinfe K Redda
Journal:  J Heterocycl Chem       Date:  2010-11-01       Impact factor: 2.193

6.  2-(1H-Benzimidazol-1-yl)-1-phenyl-ethanone.

Authors:  Ozden Ozel Güven; Taner Erdoğan; Simon J Coles; Tuncer Hökelek
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-06-28

7.  Synthesis of novel benzimidazolyl-substituted acrylonitriles and amidino-substituted benzimidazo[1,2-a]quinolines.

Authors:  Marijana Hranjec; Grace Karminski-Zamola
Journal:  Molecules       Date:  2006-08-13       Impact factor: 4.411

8.  Small Sequence-Sensitive Compounds for Specific Recognition of the G⋅C Base Pair in DNA Minor Groove.

Authors:  Abdelbasset A Farahat; Pu Guo; Hadir Shoeib; Ananya Paul; David W Boykin; W David Wilson
Journal:  Chemistry       Date:  2020-03-13       Impact factor: 5.236

9.  New (3-(1H-benzo[d]imidazol-2-yl))/(3-(3H-imidazo[4,5-b]pyridin-2-yl))-(1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors.

Authors:  Kishore Mullagiri; V Lakshma Nayak; Satish Sunkari; Geeta Sai Mani; Sravanthi Devi Guggilapu; Burri Nagaraju; Abdullah Alarifi; Ahmed Kamal
Journal:  Medchemcomm       Date:  2017-12-12       Impact factor: 3.597

10.  Novel (+)-Neoisopulegol-Based O-Benzyl Derivatives as Antimicrobial Agents.

Authors:  Tam Minh Le; Thu Huynh; Fatima Zahra Bamou; András Szekeres; Ferenc Fülöp; Zsolt Szakonyi
Journal:  Int J Mol Sci       Date:  2021-05-26       Impact factor: 5.923
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