Literature DB >> 12057556

Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool.

R Justin Davies1, Alex Freeman, Lesley S Morris, Sheila Bingham, Stephen Dilworth, Ian Scott, Ronald A Laskey, Richard Miller, Nicholas Coleman.   

Abstract

Colorectal cancer is a common disease, and more reliable screening methods are needed for early detection. We aim to develop a non-invasive, stool-based assay that can identify colorectal cancer by detection of minichromosome maintenance protein 2 (MCM2) expression in colonocytes retrieved from the faecal surface. We devised a cell line model to investigate methods and conditions for optimum colonocyte retrieval. In our clinical evaluation study, MCM2-positive cells were retrieved from 37 of 40 patients with symptomatic colorectal cancer, but from none of 25 healthy control individuals. These results suggest that immunocytochemical analysis of retrieved colonocytes might enable accurate detection of colorectal cancer in stool.

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Year:  2002        PMID： 12057556     DOI： 10.1016/S0140-6736(02)08739-1

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  45 in total

Review 1.  From gene function to improved health: genome research in the United Kingdom.

Authors:  George K Radda; Ian Viney
Journal:  J Mol Med (Berl)       Date:  2004-01-08       Impact factor: 4.599

2.  Cell cycle phase abnormalities do not account for disordered proliferation in Barrett's carcinogenesis.

Authors:  Pierre Lao-Sirieix; Rebecca Brais; Laurence Lovat; Nicholas Coleman; Rebecca C Fitzgerald
Journal:  Neoplasia       Date:  2004 Nov-Dec       Impact factor: 5.715

3.  The Croonian Lecture 2001 hunting the antisocial cancer cell: MCM proteins and their exploitation.

Authors:  Ronald Laskey
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2005-06-29       Impact factor: 6.237

Review 4.  Screening tests for colorectal cancer: a menu of options remains relevant.

Authors:  James E Allison; Michael Lawson
Journal:  Curr Oncol Rep       Date:  2006-11       Impact factor: 5.075

Review 5.  Regulating DNA replication in eukarya.

Authors:  Khalid Siddiqui; Kin Fan On; John F X Diffley
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-09-01       Impact factor: 10.005

Review 6.  Replication proteins and human disease.

Authors:  Andrew P Jackson; Ronald A Laskey; Nicholas Coleman
Journal:  Cold Spring Harb Perspect Biol       Date:  2014-01-01       Impact factor: 10.005

7.  Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation.

Authors:  Derek M Murphy; Patrick G Buckley; Kenneth Bryan; Sudipto Das; Leah Alcock; Niamh H Foley; Suzanne Prenter; Isabella Bray; Karen M Watters; Desmond Higgins; Raymond L Stallings
Journal:  PLoS One       Date:  2009-12-04       Impact factor: 3.240

Review 8.  Circulating and stool nucleic acid analysis for colorectal cancer diagnosis.

Authors:  Giulia De Maio; Claudia Rengucci; Wainer Zoli; Daniele Calistri
Journal:  World J Gastroenterol       Date:  2014-01-28       Impact factor: 5.742

9.  Biomarkers in cervical cancer.

Authors:  Eun-Kyoung Yim; Jong-Sup Park
Journal:  Biomark Insights       Date:  2007-02-07

10.  Mining for coexpression across hundreds of datasets using novel rank aggregation and visualization methods.

Authors:  Priit Adler; Raivo Kolde; Meelis Kull; Aleksandr Tkachenko; Hedi Peterson; Jüri Reimand; Jaak Vilo
Journal:  Genome Biol       Date:  2009-12-04       Impact factor: 13.583
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