Literature DB >> 12055825

Drug sensitivity of Leishmania species: some unresolved problems.

Simon L Croft1, Vanessa Yardley, Howard Kendrick.   

Abstract

Leishmania species show a significant variation in their sensitivity to established and experimental drugs. Molecular techniques to identify species in clinical infections rapidly could be used to guide treatment. Molecular markers are required to detect and monitor acquired resistance to antimonial drugs. Reporter genes and the polymerase chain reaction will improve assays both in vitro and in vivo for the identification and evaluation of new drugs.

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Year:  2002        PMID： 12055825     DOI： 10.1016/s0035-9203(02)90063-5

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  12 in total

Review 1.  Potential of Piper spp. as a source of new compounds for the leishmaniases treatment.

Authors:  Juliana Figueiredo Peixoto; Ygor Jessé Ramos; Davyson de Lima Moreira; Carlos Roberto Alves; Luiz Filipe Gonçalves-Oliveira
Journal:  Parasitol Res       Date:  2021-07-10       Impact factor: 2.289

2.  Use of PCR-restriction fragment length polymorphism analysis to identify the main new world Leishmania species and analyze their taxonomic properties and polymorphism by application of the assay to clinical samples.

Authors:  Brice Rotureau; Christophe Ravel; Pierre Couppié; Francine Pratlong; Mathieu Nacher; Jean-Pierre Dedet; Bernard Carme
Journal:  J Clin Microbiol       Date:  2006-02       Impact factor: 5.948

3.  Genetic markers for SSG resistance in Leishmania donovani and SSG treatment failure in visceral leishmaniasis patients of the Indian subcontinent.

Authors:  Manu Vanaerschot; Saskia Decuypere; Tim Downing; Hideo Imamura; Olivia Stark; Simonne De Doncker; Syamal Roy; Bart Ostyn; Louis Maes; Basudha Khanal; Marleen Boelaert; Gabriele Schönian; Matthew Berriman; François Chappuis; Jean-Claude Dujardin; Shyam Sundar; Suman Rijal
Journal:  J Infect Dis       Date:  2012-06-29       Impact factor: 5.226

4.  Primary oral Penicillium marneffei infection diagnosed by PCR-based molecular identification and transmission electron microscopic observation from formalin-fixed paraffin-embedded tissues.

Authors:  Xia Hua; Ruifeng Zhang; Hanjun Yang; Song Lei; Yizhi Zhang; Yuping Ran
Journal:  Med Mycol Case Rep       Date:  2012-11-07

5.  Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds.

Authors:  Jair L Siqueira-Neto; Ok-Ryul Song; Hyunrim Oh; Jeong-Hun Sohn; Gyongseon Yang; Jiyoun Nam; Jiyeon Jang; Jonathan Cechetto; Chang Bok Lee; Seunghyun Moon; Auguste Genovesio; Eric Chatelain; Thierry Christophe; Lucio H Freitas-Junior
Journal:  PLoS Negl Trop Dis       Date:  2010-05-04

6.  Insights into the structural patterns of the antileishmanial activity of bi- and tricyclic N-heterocycles.

Authors:  Lizzi Herrera; David E Stephens; Abigail D'Avila; Kathryn G George; Hadi Arman; Yu Zhang; George Perry; Ricardo Lleonart; Oleg V Larionov; Patricia L Fernández
Journal:  Org Biomol Chem       Date:  2016-07-04       Impact factor: 3.876

7.  Second-generation pterocarpanquinones: synthesis and antileishmanial activity.

Authors:  Viviane Dos Santos Faiões; Lívia C R M da Frota; Edézio Ferreira Cunha-Junior; Julio C F Barcellos; Thayssa Da Silva; Chaquip Daher Netto; Silvia Amaral Gonçalves Da-Silva; Alcides J M da Silva; Paulo R R Costa; Eduardo Caio Torres-Santos
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2018-11-29

8.  In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp.

Authors:  Juliana Figueiredo Peixoto; Adriane da Silva Oliveira; Patrícia Queiroz Monteiro; Luiz Filipe Gonçalves-Oliveira; Valter Viana Andrade-Neto; Vitor Francisco Ferreira; Franklin Souza-Silva; Carlos Roberto Alves
Journal:  Molecules       Date:  2021-06-10       Impact factor: 4.411

9.  Antileishmanial Activity of Compounds Derived from the Medicines for Malaria Venture Open Access Box Against Intracellular Leishmania major Amastigotes.

Authors:  Mozna Khraiwesh; Susan Leed; Norma Roncal; Jacob Johnson; Richard Sciotti; Philip Smith; Lisa Read; Robert Paris; Thomas Hudson; Mark Hickman; Max Grogl
Journal:  Am J Trop Med Hyg       Date:  2015-10-26       Impact factor: 2.345

10.  A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity.

Authors:  Laura M Alcântara; Thalita C S Ferreira; Vanessa Fontana; Eric Chatelain; Carolina B Moraes; Lucio H Freitas-Junior
Journal:  Molecules       Date:  2020-05-30       Impact factor: 4.411
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