Literature DB >> 27376396

Insights into the structural patterns of the antileishmanial activity of bi- and tricyclic N-heterocycles.

Lizzi Herrera1, David E Stephens, Abigail D'Avila, Kathryn G George, Hadi Arman, Yu Zhang, George Perry, Ricardo Lleonart, Oleg V Larionov, Patricia L Fernández.   

Abstract

The influence of various structural patterns in a series of novel bi- and tricyclic N-heterocycles on the activity against Leishmania major and Leishmania panamensis has been studied and compounds that are active in the low micromolar region have been identified. Both quinolines and tetrahydrooxazinoindoles (TOI) proved to have significant antileishmanial activities, while substituted indoles were inactive. We have also showed that a chloroquine analogue induces Leishmania killing by modulating macrophage activation.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 27376396      PMCID： PMC4958403          DOI： 10.1039/c6ob01149g

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  42 in total

1.  Disseminated cutaneous leishmaniasis resembling post-kala-azar dermal leishmaniasis caused by Leishmania donovani in three patients co-infected with visceral leishmaniasis and human immunodeficiency virus/acquired immunodeficiency syndrome in Ethiopia.

Authors:  Tesfaye Gelanew; Zewdu Hurissa; Ermias Diro; Aysheshm Kassahun; Katrin Kuhls; Gabriele Schönian; Asrat Hailu
Journal:  Am J Trop Med Hyg       Date:  2011-06       Impact factor: 2.345

2.  Differential sensitivity of C57BL/6 (M-1) and BALB/c (M-2) macrophages to the stimuli of IFN-gamma/LPS for the production of NO: correlation with iNOS mRNA and protein expression.

Authors:  Jane L Santos; Anderson A Andrade; Adriana A M Dias; Cláudio A Bonjardim; Luiz F L Reis; Santuza M R Teixeira; M Fátima Horta
Journal:  J Interferon Cytokine Res       Date:  2006-09       Impact factor: 2.607

3.  Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides.

Authors:  Oleg V Larionov; David Stephens; Adelphe Mfuh; Gabriel Chavez
Journal:  Org Lett       Date:  2014-01-10       Impact factor: 6.005

4.  The role of IL-10 in promoting disease progression in leishmaniasis.

Authors:  M M Kane; D M Mosser
Journal:  J Immunol       Date:  2001-01-15       Impact factor: 5.422

5.  Quinoline-based compounds as modulators of HIV transcription through NF-kappaB and Sp1 inhibition.

Authors:  Luis Miguel Bedoya; María José Abad; Esther Calonge; Luis Astudillo Saavedra; Margarita Gutierrez C; Vladimir V Kouznetsov; José Alcami; Paulina Bermejo
Journal:  Antiviral Res       Date:  2010-06-23       Impact factor: 5.970

Review 6.  Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents.

Authors:  A M Mfuh; O V Larionov
Journal:  Curr Med Chem       Date:  2015       Impact factor: 4.530

7.  Concise Total Synthesis of Trichodermamides A, B, and C Enabled by an Efficient Construction of the 1,2-Oxazadecaline Core.

Authors:  Adelphe M Mfuh; Yu Zhang; David E Stephens; Anh X T Vo; Hadi D Arman; Oleg V Larionov
Journal:  J Am Chem Soc       Date:  2015-06-22       Impact factor: 15.419

8.  Influence of Leishmania (Viannia) species on the response to antimonial treatment in patients with American tegumentary leishmaniasis.

Authors:  Jorge Arevalo; Luis Ramirez; Vanessa Adaui; Mirko Zimic; Gianfranco Tulliano; César Miranda-Verástegui; Marcela Lazo; Raúl Loayza-Muro; Simonne De Doncker; Anne Maurer; Francois Chappuis; Jean-Claude Dujardin; Alejandro Llanos-Cuentas
Journal:  J Infect Dis       Date:  2007-05-03       Impact factor: 5.226

Review 9.  The quinolone family: from antibacterial to anticancer agents.

Authors:  Claudia Sissi; Manlio Palumbo
Journal:  Curr Med Chem Anticancer Agents       Date:  2003-11

Review 10.  Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria.

Authors:  Jane Achan; Ambrose O Talisuna; Annette Erhart; Adoke Yeka; James K Tibenderana; Frederick N Baliraine; Philip J Rosenthal; Umberto D'Alessandro
Journal:  Malar J       Date:  2011-05-24       Impact factor: 2.979
View more
  2 in total

1.  Identification of Inhibitors of CD36-Amyloid Beta Binding as Potential Agents for Alzheimer's Disease.

Authors:  Deborah Doens; Pedro A Valiente; Adelphe M Mfuh; Anh X T Vo; Adilia Tristan; Lizmar Carreño; Mario Quijada; Vu T Nguyen; George Perry; Oleg V Larionov; Ricardo Lleonart; Patricia L Fernández
Journal:  ACS Chem Neurosci       Date:  2017-02-15       Impact factor: 4.418

2.  Modular Three-Component Synthesis of 4-Aminoquinolines via an Imidoylative Sonogashira/Cyclization Cascade.

Authors:  Jurriën W Collet; Kelly Ackermans; Jeffrey Lambregts; Bert U W Maes; Romano V A Orru; Eelco Ruijter
Journal:  J Org Chem       Date:  2018-01-02       Impact factor: 4.354
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.