Literature DB >> 12055815

Clinical efficacy of chloroquine or sulfadoxine-pyrimethamine in children under five from south-western Uganda with uncomplicated falciparum malaria.

D Legros1, K Johnson, P Houpikian, M Makanga, J K Kabakyenga, A O Talisuna, W R J Taylor.   

Abstract

We conducted a 14-day study (during March-May 1998) to assess the efficacy of chloroquine and sulfadoxine-pyrimethamine (SP) for treating uncomplicated Plasmodium falciparum malaria in Uganda. Overall treatment failure rates were 43 (81.1%) of 53 chloroquine recipients and 16 (25.0%) of 64 SP patients. Strategies to improve the life-span of standard and affordable anti-malarial drugs are needed.

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Year:  2002        PMID： 12055815     DOI： 10.1016/s0035-9203(02)90304-4

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  9 in total

Review 1.  History, dynamics, and public health importance of malaria parasite resistance.

Authors:  Ambrose O Talisuna; Peter Bloland; Umberto D'Alessandro
Journal:  Clin Microbiol Rev       Date:  2004-01       Impact factor: 26.132

2.  In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up.

Authors:  Kasia Stepniewska; Walter R J Taylor; Mayfong Mayxay; Ric Price; Frank Smithuis; Jean-Paul Guthmann; Karen Barnes; Hla Yin Myint; Martin Adjuik; Piero Olliaro; Sasithon Pukrittayakamee; Sornchai Looareesuwan; Tran Tinh Hien; Jeremy Farrar; François Nosten; Nicholas P J Day; Nicholas J White
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

3.  In vitro activities of 2,4-diaminoquinazoline and 2,4-diaminopteridine derivatives against Plasmodium falciparum.

Authors:  Sheila Ommeh; Eunice Nduati; Eddy Mberu; Gilbert Kokwaro; Kevin Marsh; Andre Rosowsky; Alexis Nzila
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

4.  A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trial.

Authors: 
Journal:  PLoS Med       Date:  2011-11-08       Impact factor: 11.069

5.  Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda.

Authors:  Francesco Checchi; Patrice Piola; Carole Fogg; Francis Bajunirwe; Samuel Biraro; Francesco Grandesso; Eugene Ruzagira; Joseph Babigumira; Isaac Kigozi; James Kiguli; Juliet Kyomuhendo; Laurent Ferradini; Walter R J Taylor; Jean-Paul Guthmann
Journal:  Malar J       Date:  2006-07-19       Impact factor: 2.979

6.  Assay for screening for six antimalarial drugs and one metabolite using dried blood spot sampling, sequential extraction and ion-trap detection.

Authors:  Daniel Blessborn; Susanne Romsing; Yngve Bergqvist; Niklas Lindegardh
Journal:  Bioanalysis       Date:  2010-11       Impact factor: 2.681

7.  Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial.

Authors:  Victoria Nakibuuka; Grace Ndeezi; Deborah Nakiboneka; Christopher M Ndugwa; James K Tumwine
Journal:  Malar J       Date:  2009-10-24       Impact factor: 2.979

8.  Efficacy of Pyrimethamine/Sulfadoxine versus Chloroquine for the Treatment of Uncomplicated Falciparum Malaria in Children Aged Under 5 Years.

Authors:  W Zheng; H Jiang; Z Xiong; Z Jiang; H Chen
Journal:  Iran J Parasitol       Date:  2013-01       Impact factor: 1.012

9.  Assessing antimalarial efficacy in a time of change to artemisinin-based combination therapies: the role of Médecins Sans Frontières.

Authors:  Jean-Paul Guthmann; Francesco Checchi; Ingrid van den Broek; Suna Balkan; Michel van Herp; Eric Comte; Oscar Bernal; Jean-Marie Kindermans; Sarah Venis; Dominique Legros; Philippe J Guerin
Journal:  PLoS Med       Date:  2008-08-05       Impact factor: 11.069
  9 in total

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