| Literature DB >> 12053279 |
Rossana Berti1, Meghan B Brennan, Samantha S Soldan, Joan M Ohayon, Luca Casareto, Henry F McFarland, Steven Jacobson.
Abstract
In recent years, human herpesvirus 6 (HHV-6) has been investigated as a possible causative agent for MS. To determine if the detection of HHV-6 DNA in the serum of MS patients correlates with clinical parameters of MS disease progression, a total of 215 serum samples was obtained from 59 MS patients followed prospectively for a 5-month period. These samples were analyzed for the presence of HHV-6 DNA by nested PCR and compared in parallel to MS disease activity. HHV-6 DNA was amplified in 22% (4/18) of samples obtained during a period of clinical exacerbation. Significantly fewer (P = 0.008) sera, 5.6% (11/197), obtained from MS patients during clinical remission tested positive for the presence of HHV-6 DNA. This work demonstrates that the detection of serum HHV-6 DNA is significantly correlated with clinical exacerbations in MS. Moreover, the findings presented in this study have confirmed previous reports supporting an association between MS and HHV-6 and suggest a role for this human herpesvirus in the pathogenesis of MS.Entities:
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Year: 2002 PMID： 12053279 DOI： 10.1080/13550280290049615-1
Source DB: PubMed Journal: J Neurovirol ISSN： 1355-0284 Impact factor: 2.643