Literature DB >> 12050357

Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus challenge in rabbits.

Jiafen Hu1, Ricai Han, Nancy M Cladel, Martin D Pickel, Neil D Christensen.   

Abstract

The cottontail rabbit papillomavirus (CRPV)-rabbit model has been used in several studies for testing prophylactic and therapeutic papillomavirus vaccines. Earlier observations had shown that the CRPV nonstructural genes E1, E2, and E6 induced strong to partial protective immunity against CRPV infection. In this study, we found that CRPV E8 immunization eliminated virus-induced papillomas in EIII/JC inbred rabbits (100%) and provided partial protection (55%) against virus challenge in outbred New Zealand White rabbits. CRPV-E8 is a small open reading frame, coding for a 50-amino-acid protein, that is colinear with the CRPV E6 gene and has features similar to those of the bovine papillomavirus and human papillomavirus E5 genes. Papillomas that grew on E8-vaccinated outbred rabbits were significantly smaller than those on vector-vaccinated rabbits (P < 0.01; t test). Delayed-type hypersensitivity skin tests showed that some of the E8-vaccinated rabbits had positive responses to E8-specific peptides.

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Year:  2002        PMID： 12050357      PMCID： PMC136259          DOI： 10.1128/jvi.76.13.6453-6459.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  48 in total

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Authors:  D DiMaio; D Mattoon
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Authors:  J B Ulmer; J C Sadoff; M A Liu
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3.  Virus-like particles of bovine papillomavirus type 4 in prophylactic and therapeutic immunization.

Authors:  R Kirnbauer; L M Chandrachud; B W O'Neil; E R Wagner; G J Grindlay; A Armstrong; G M McGarvie; J T Schiller; D R Lowy; M S Campo
Journal:  Virology       Date:  1996-05-01       Impact factor: 3.616

Review 4.  DNA vaccines.

Authors:  W M McDonnell; F K Askari
Journal:  N Engl J Med       Date:  1996-01-04       Impact factor: 91.245

5.  Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7.

Authors:  R Höpfl; K Heim; N Christensen; K Zumbach; U Wieland; B Volgger; A Widschwendter; S Haimbuchner; E Müller-Holzner; M Pawlita; H Pfister; P Fritsch
Journal:  Lancet       Date:  2000-12-09       Impact factor: 79.321

Review 6.  The immunology of animal papillomaviruses.

Authors:  P K Nicholls; M A Stanley
Journal:  Vet Immunol Immunopathol       Date:  2000-02-25       Impact factor: 2.046

7.  Immunization with viruslike particles induces long-term protection of rabbits against challenge with cottontail rabbit papillomavirus.

Authors:  N D Christensen; C A Reed; N M Cladel; R Han; J W Kreider
Journal:  J Virol       Date:  1996-02       Impact factor: 5.103

8.  Coincidental expression of E5a and c-jun in human papillomavirus type 6/11-infected condylomata.

Authors:  S L Chen; T B Hsieh; Y P Tsao; C P Han; Y F Yang
Journal:  J Gen Virol       Date:  1996-06       Impact factor: 3.891

9.  The E5 protein of HPV-6, but not HPV-16, associates efficiently with cellular growth factor receptors.

Authors:  M Conrad; D Goldstein; T Andresson; R Schlegel
Journal:  Virology       Date:  1994-05-01       Impact factor: 3.616

10.  Golgi alkalinization by the papillomavirus E5 oncoprotein.

Authors:  F Schapiro; J Sparkowski; A Adduci; F Suprynowicz; R Schlegel; S Grinstein
Journal:  J Cell Biol       Date:  2000-01-24       Impact factor: 10.539
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  23 in total

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Authors:  Jiafen Hu; Nancy Cladel; Karla Balogh; Neil Christensen
Journal:  Vaccine       Date:  2010-03-21       Impact factor: 3.641

2.  Secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with Mus musculus papillomavirus 1 DNA and virus.

Authors:  Nancy M Cladel; Lynn R Budgeon; Timothy K Cooper; Karla K Balogh; Jiafen Hu; Neil D Christensen
Journal:  J Virol       Date:  2013-06-19       Impact factor: 5.103

3.  BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo.

Authors:  Mary A Morse; Karla K Balogh; Sarah A Brendle; Colin A Campbell; Mao X Chen; Rebecca C Furze; Isobel L Harada; Ian D Holyer; Umesh Kumar; Kevin Lee; Rab K Prinjha; Martin Rüdiger; Jonathan T Seal; Simon Taylor; Jason Witherington; Neil D Christensen
Journal:  Antiviral Res       Date:  2018-04-11       Impact factor: 5.970

4.  Amino acid residues in the carboxy-terminal region of cottontail rabbit papillomavirus E6 influence spontaneous regression of cutaneous papillomas.

Authors:  Jiafen Hu; Nancy M Cladel; Martin D Pickel; Neil D Christensen
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

5.  Using HLA-A2.1 Transgenic Rabbit Model to Screen and Characterize New HLA-A2.1 Restricted Epitope DNA Vaccines.

Authors:  Jiafen Hu; Todd D Schell; Xuwen Peng; Nancy M Cladel; Karla K Balogh; Neil D Christensen
Journal:  J Vaccines Vaccin       Date:  2010-08-20

6.  Cottontail rabbit papillomavirus E8 protein is essential for wart formation and provides new insights into viral pathogenesis.

Authors:  Mathieu Nonnenmacher; Jérôme Salmon; Yves Jacob; Gérard Orth; Françoise Breitburd
Journal:  J Virol       Date:  2006-05       Impact factor: 5.103

7.  Cross-protective efficacy of a prophylactic Leishmania donovani DNA vaccine against visceral and cutaneous murine leishmaniasis.

Authors:  Ingrid Aguilar-Be; Renata da Silva Zardo; Edilma Paraguai de Souza; Gulnara Patrícia Borja-Cabrera; Miguel Rosado-Vallado; Mirza Mut-Martin; Maria del Rosario García-Miss; Clarisa Beatriz Palatnik de Sousa; Eric Dumonteil
Journal:  Infect Immun       Date:  2005-02       Impact factor: 3.441

8.  Vaccine generated immunity targets an HPV16 E7 HLA-A2.1-restricted CD8(+) T cell epitope relocated to an early gene or a late gene of the cottontail rabbit papillomavirus (CRPV) genome in HLA-A2.1 transgenic rabbits.

Authors:  Callie E Bounds; Jiafen Hu; Nancy M Cladel; Karla Balogh; Neil D Christensen
Journal:  Vaccine       Date:  2010-12-16       Impact factor: 3.641

9.  Establishment of a cottontail rabbit papillomavirus/HLA-A2.1 transgenic rabbit model.

Authors:  Jiafen Hu; Xuwen Peng; Lynn R Budgeon; Nancy M Cladel; Karla K Balogh; Neil D Christensen
Journal:  J Virol       Date:  2007-04-25       Impact factor: 5.103

10.  Wounding prior to challenge substantially improves infectivity of cottontail rabbit papillomavirus and allows for standardization of infection.

Authors:  Nancy M Cladel; Jiafen Hu; Karla Balogh; Andres Mejia; Neil D Christensen
Journal:  J Virol Methods       Date:  2007-12-03       Impact factor: 2.014
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