| Literature DB >> 17459918 |
Jiafen Hu1, Xuwen Peng, Lynn R Budgeon, Nancy M Cladel, Karla K Balogh, Neil D Christensen.
Abstract
Three transgenic rabbit lines that express a well-characterized human major histocompatibility complex class I (MHC-I) gene (HLA-A2.1) have been established. All three lines carry the HLA-A2.1 heavy chain and are able to pass the transgene to their offspring with both the outbred and the inbred EIII/JC genetic background. HLA-A2.1 colocalizes exclusively with rabbit MHC-I on the cell surfaces. These HLA-A2.1 transgenic rabbits demonstrated infection patterns similar to those found after cottontail rabbit papillomavirus (CRPV) challenge when compared with results in normal rabbits, although higher regression rates were found in HLA-A2.1 transgenic rabbits. Because the CRPV genome can accommodate significant modifications, the CRPV/HLA-A2.1 rabbit model has the potential to be used to screen HLA-A2.1-restricted immunogenic epitopes from human papillomaviruses in the context of in vivo papillomavirus infection.Entities:
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Year: 2007 PMID： 17459918 PMCID： PMC1933279 DOI： 10.1128/JVI.00200-07
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103