BACKGROUND: Ultrathin-section 3-dimensional fast spin-echo (3-D FSE) T2-weighted imaging is a new magnetic resonance imaging (MRI) technique that we used in the evaluation of ocular and orbital malignancies. We evaluated the usefulness of this new technique compared with conventional MRI. METHODS: Imaging data from 26 consecutive patients seen in the Ocular Oncology Unit at the University of California-San Francisco were retrospectively reviewed by physicians from the ocular oncology and neuroradiology units. For all patients, 3-D FSE T2-weighted images (27 scans) were compared with results of conventional MRI and correlated with results of computed tomography (CT), A- and B-scan ultrasonography, ultrasound biomicroscopy, clinical examinations, and histopathology, when available. RESULTS: The 3-D FSE T2-weighted imaging sequence resulted in an overall improvement in accuracy of imaging findings in 17 (63%) of our 27 cases compared with the standard MRI protocol. The increased resolution led to the radiographic detection of additional lesions in 11 (41%) of 27 cases and to an increase in confidence in radiographic diagnosis in 6 (22%) of the remaining cases. The improved resolution of the 3-D FSE T2-weighted sequence resulted in a change of disease management in 3 (60%) of the 5 patients with nonretinoblastoma lesions. One hundred percent of active retinoblastoma lesions could be detected by means of 3-D FSE and conventional imaging; however, inactive lesions were not always detected using conventional imaging. CONCLUSIONS: The 3-D FSE T2-weighted sequence offers superior resolution of intraocular and orbital structures compared with conventional MRI. It is particularly useful in the evaluation of intraocular tumors and the nerve-sheath complex. This new technique contributes significantly to improved diagnosis and management in patients with ocular and orbital malignancies.
BACKGROUND: Ultrathin-section 3-dimensional fast spin-echo (3-D FSE) T2-weighted imaging is a new magnetic resonance imaging (MRI) technique that we used in the evaluation of ocular and orbital malignancies. We evaluated the usefulness of this new technique compared with conventional MRI. METHODS: Imaging data from 26 consecutive patients seen in the Ocular Oncology Unit at the University of California-San Francisco were retrospectively reviewed by physicians from the ocular oncology and neuroradiology units. For all patients, 3-D FSE T2-weighted images (27 scans) were compared with results of conventional MRI and correlated with results of computed tomography (CT), A- and B-scan ultrasonography, ultrasound biomicroscopy, clinical examinations, and histopathology, when available. RESULTS: The 3-D FSE T2-weighted imaging sequence resulted in an overall improvement in accuracy of imaging findings in 17 (63%) of our 27 cases compared with the standard MRI protocol. The increased resolution led to the radiographic detection of additional lesions in 11 (41%) of 27 cases and to an increase in confidence in radiographic diagnosis in 6 (22%) of the remaining cases. The improved resolution of the 3-D FSE T2-weighted sequence resulted in a change of disease management in 3 (60%) of the 5 patients with nonretinoblastoma lesions. One hundred percent of active retinoblastoma lesions could be detected by means of 3-D FSE and conventional imaging; however, inactive lesions were not always detected using conventional imaging. CONCLUSIONS: The 3-D FSE T2-weighted sequence offers superior resolution of intraocular and orbital structures compared with conventional MRI. It is particularly useful in the evaluation of intraocular tumors and the nerve-sheath complex. This new technique contributes significantly to improved diagnosis and management in patients with ocular and orbital malignancies.
Authors: Erin M Simon; Sharon McCaffery; Howard A Rowley; Nancy J Fischbein; Ann Shimikawa; Joan M O'Brien Journal: Neuroradiology Date: 2003-06-11 Impact factor: 2.804
Authors: Bruce M Buerk; Jose S Pulido; Ignacio Chiong; Robert Folberg; Deepak P Edward; Mark T Duffy; Keith R Thulborn Journal: Trans Am Ophthalmol Soc Date: 2004
Authors: K Tanitame; T Sone; T Miyoshi; N Tanitame; K Otani; Y Akiyama; M Takasu; S Date; Y Kiuchi; K Awai Journal: AJNR Am J Neuroradiol Date: 2012-10-04 Impact factor: 3.825
Authors: Alberto Mejía-Novelo; Alberto Alvarado-Miranda; Flavia Morales-Vázquez; Carlos Gamboa-Vignole; Rodrigo Núñez-Gómez; Noel Castañeda-Soto; Alfonso Dueñas-González; Myrna Candelaria-Hernández; Fernando Lara-Medina Journal: Med Oncol Date: 2004 Impact factor: 3.064
Authors: A Dieing; C-O Schulz; P Schmid; A C Roever; S Lehenbauer-Dehm; C Jehn; B Flath; K Possinger Journal: J Cancer Res Clin Oncol Date: 2004-09-07 Impact factor: 4.553