Literature DB >> 1204793

Conformations and biological properties of apomorphine and its phenanthro(10,1-b,c)azepine homologue.

D Berney, T J Petcher, J Schmutz, H P Weber, T G White.   

Abstract

11,12-Dihydroxy-7-methyl-4,5,6,7,7a,8-hexahydrophenanthro[10,1-b,c]-azepine (2), a homologue of apomorphine (1), has been found to be devoid of dopaminergic effects. The biological differences between apomorphine and this homologue are explained in terms of differences in conformation of the two molecules.

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Year:  1975        PMID: 1204793     DOI: 10.1007/bf01945809

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  4 in total

1.  Synthesis and biological activity of (6aS)-10,11-dihydroxyaporphine, the optical antipode of apomorphine.

Authors:  W S Saari; S W King
Journal:  J Med Chem       Date:  1973-02       Impact factor: 7.446

2.  The structure of the catecholamines. II. The crystal structure of dopamine hydrochloride.

Authors:  R Bergin; D Carlström
Journal:  Acta Crystallogr B       Date:  1968-11-15       Impact factor: 2.266

3.  Aporphines. 8. Total synthesis and pharmacological evaluation of (plus or minus)-apomorphine, (plus or minus)-apocodeine, (plus or minus)-N-n-propylnorapomorphine, and (plus or minus)-N-n-propylnorapocodeine.

Authors:  J L Neumeyer; B R Neustadt; K H Oh; K K Weinhardt; C B Boyce; F J Rosenberg; D G Teiger
Journal:  J Med Chem       Date:  1973-11       Impact factor: 7.446

4.  Optical rotatory dispersion and absolute configuration. II. Aporphine alkaloids.

Authors:  J C Craig; S K Roy
Journal:  Tetrahedron       Date:  1965-02       Impact factor: 2.457

  4 in total
  1 in total

1.  Structure-activity relationships for apomorphine congeners. Conformational energies vs. biological activities.

Authors:  I Pettersson; T Liljefors
Journal:  J Comput Aided Mol Des       Date:  1987-07       Impact factor: 3.686

  1 in total

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