Literature DB >> 12044032

DNAzymes: cutting a path to a new class of therapeutics.

Levon M Khachigian1.   

Abstract

DNAzymes are synthetic catalytic deoxyribonucleic acid molecules that can be engineered to bind to their complementary sequence in the target nucleic acid through Watson-Crick base pairing and cleave at predetermined phosphodiester linkages. This article reviews the recent use of DNAzymes as probes of molecular function and their potential applications in clinical medicine.

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Year:  2002        PMID： 12044032

Source DB:  PubMed          Journal:  Curr Opin Mol Ther        ISSN： 1464-8431


  8 in total

1.  RNA cleaving '10-23' DNAzymes with enhanced stability and activity.

Authors:  Steffen Schubert; Deniz C Gül; Hans-Peter Grunert; Heinz Zeichhardt; Volker A Erdmann; Jens Kurreck
Journal:  Nucleic Acids Res       Date:  2003-10-15       Impact factor: 16.971

2.  A novel replicating circular DNAzyme.

Authors:  Fei Chen; Ruijian Wang; Zhe Li; Bin Liu; Xiaoping Wang; Yanhong Sun; Dongyun Hao; Jin Zhang
Journal:  Nucleic Acids Res       Date:  2004-04-28       Impact factor: 16.971

3.  Zn2+-dependent deoxyribozymes that form natural and unnatural RNA linkages.

Authors:  Kelly A Hoadley; Whitney E Purtha; Amanda C Wolf; Amber Flynn-Charlebois; Scott K Silverman
Journal:  Biochemistry       Date:  2005-06-28       Impact factor: 3.162

4.  Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth.

Authors:  Roger G Fahmy; Levon M Khachigian
Journal:  Nucleic Acids Res       Date:  2004-04-23       Impact factor: 16.971

5.  Prevention of neointimal hyperplasia in balloon-injured rat carotid artery via small interference RNA mediated downregulation of osteopontin gene.

Authors:  Jian Xu; Yingxian Sun; Tairan Wang; Guinan Liu
Journal:  Mol Cell Biochem       Date:  2013-03-07       Impact factor: 3.396

Review 6.  In vitro selection, characterization, and application of deoxyribozymes that cleave RNA.

Authors:  Scott K Silverman
Journal:  Nucleic Acids Res       Date:  2005-11-11       Impact factor: 16.971

7.  Design of efficient DNAzymes against muscle AChR alpha-subunit cRNA in vitro and in HEK 293 cells.

Authors:  Amr Abdelgany; M Khabir Uddin; Matthew Wood; Kazunari Taira; David Beeson
Journal:  J RNAi Gene Silencing       Date:  2005-10-14

8.  Selective DNAzyme-mediated cleavage of AChR mutant transcripts by targeting the mutation site or through mismatches in the binding arm.

Authors:  Amr Abdelgany; John Ealing; Matthew Wood; David Beeson
Journal:  J RNAi Gene Silencing       Date:  2005-07-28
  8 in total

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