AIMS: To compare the precursor of atrial and brain natriuretic peptide (N-ANP, N-BNP), brain natriuretic peptide (BNP), big endothelin-1, the 6-min walk test and the Minnesota Living with Heart Failure Questionnaire (LHFQ) with regard to short-term outcome in an ambulatory heart failure population. METHODS AND RESULTS: Ninety-six individuals (left ventricular ejection fraction of 26+/-10%) were included in the study. Within 1 day blood samples of N-ANP, N-BNP, BNP and big endothelin-1 were obtained, and the 6-min walk test and LHFQ were measured. The predictive power of these variables - including renin-angiotensin system antagonist therapy - in respect of 1-year event-free survival were calculated with a Cox regression analysis. All investigated variables had the power to predict outcome in a univariate analysis. Multivariate analysis revealed that N-ANP (chi-square=58 P<0.0001), BNP (chi-square=8 P<0.01), the LHFQ (chi-square=6 P<0.02) and the renin-angiotensin system antagonist (chi-square=4 P<0.05), are independent predictors. CONCLUSION: We conclude that, in an open clinical cohort of patients with large differences in the progression of the disease, N-ANP, BNP and LHFQ are the most reliable predictors of worsening heart failure in the short term. However, the dosage of the ACE inhibitor influenced short-term survival in this population. Copyright 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved.
AIMS: To compare the precursor of atrial and brain natriuretic peptide (N-ANP, N-BNP), brain natriuretic peptide (BNP), big endothelin-1, the 6-min walk test and the Minnesota Living with Heart Failure Questionnaire (LHFQ) with regard to short-term outcome in an ambulatory heart failure population. METHODS AND RESULTS: Ninety-six individuals (left ventricular ejection fraction of 26+/-10%) were included in the study. Within 1 day blood samples of N-ANP, N-BNP, BNP and big endothelin-1 were obtained, and the 6-min walk test and LHFQ were measured. The predictive power of these variables - including renin-angiotensin system antagonist therapy - in respect of 1-year event-free survival were calculated with a Cox regression analysis. All investigated variables had the power to predict outcome in a univariate analysis. Multivariate analysis revealed that N-ANP (chi-square=58 P<0.0001), BNP (chi-square=8 P<0.01), the LHFQ (chi-square=6 P<0.02) and the renin-angiotensin system antagonist (chi-square=4 P<0.05), are independent predictors. CONCLUSION: We conclude that, in an open clinical cohort of patients with large differences in the progression of the disease, N-ANP, BNP and LHFQ are the most reliable predictors of worsening heart failure in the short term. However, the dosage of the ACE inhibitor influenced short-term survival in this population. Copyright 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved.
Authors: Ravishankar Jayadevappa; Jerry C Johnson; Bernard S Bloom; Sanford Nidich; Shashank Desai; Sumedha Chhatre; Donna B Raziano; Robert Schneider Journal: Ethn Dis Date: 2007 Impact factor: 1.847
Authors: Massimo Volpe; Pietro Francia; Giuliano Tocci; Speranza Rubattu; Sara Cangianiello; Maria Assunta Elena Rao; Bruno Trimarco; Mario Condorelli Journal: Clin Cardiol Date: 2010-11 Impact factor: 2.882
Authors: Martin Scherer; Wolfgang Himmel; Beate Stanske; Franziska Scherer; Janka Koschack; Michael M Kochen; Christoph Herrmann-Lingen Journal: Br J Gen Pract Date: 2007-10 Impact factor: 5.386
Authors: Martin Scherer; Wolfgang Himmel; Michael M Kochen; Janka Koschack; Dirk Ahrens; Jean-Francois Chenot; Anne Simmenroth-Nayda; Christoph Herrmann-Lingen Journal: Psychosoc Med Date: 2008-04-02