Literature DB >> 12040429

The configuration of the immunoglobulin genes in B cell chronic lymphocytic leukemia.

M J S Dyer1, D G Oscier.   

Abstract

B cell chronic lymphocytic leukemia (CLL) lacks a consistent genetic abnormality. However, immunoglobulin V(H) gene segment mutation analysis has provided insights into the pathogenesis of these diseases and allowed the development of powerful prognostic markers. Immunoglobulin gene chromosomal translocations are rare in CLL and involve a distinct subset of genes including BCL3, BCL11A and CCND2. BCL2 translocations in CLL appear to arise via a different mechanism from comparable translocations seen in B cell non-Hodgkin lymphoma.

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Year:  2002        PMID： 12040429     DOI： 10.1038/sj.leu.2402528

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


  6 in total

1.  Telomeric IGH losses detectable by fluorescence in situ hybridization in chronic lymphocytic leukemia reflect somatic VH recombination events.

Authors:  Iwona Wlodarska; Christine Matthews; Ellen Veyt; Helena Pospisilova; Mark A Catherwood; Tim S Poulsen; Vera Vanhentenrijk; Rachel Ibbotson; Peter Vandenberghe; T C M Curly Morris; H Denis Alexander
Journal:  J Mol Diagn       Date:  2007-02       Impact factor: 5.568

2.  BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression.

Authors:  Thanaset Senawong; Valerie J Peterson; Mark Leid
Journal:  Arch Biochem Biophys       Date:  2005-02-15       Impact factor: 4.013

Review 3.  Prognostic factors in chronic lymphocytic leukemia-what do we need to know?

Authors:  Paula Cramer; Michael Hallek
Journal:  Nat Rev Clin Oncol       Date:  2010-10-19       Impact factor: 66.675

Review 4.  Molecular diagnosis in lymphoma.

Authors:  Adam Bagg
Journal:  Curr Oncol Rep       Date:  2004-09       Impact factor: 5.075

5.  Interphase fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia.

Authors:  Wei Xu; Jian-Yong Li; Jin-Lan Pan; Hai-Rong Qiu; Yun-Feng Shen; Li Li; Ya-Fang Wu; Yong-Quan Xue
Journal:  Int J Hematol       Date:  2007-06       Impact factor: 2.490

6.  Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies.

Authors:  Zijun Y Xu-Monette; Jianyong Li; Yi Xia; Beryl Crossley; Robert D Bremel; Yi Miao; Min Xiao; Thomas Snyder; Ganiraju C Manyam; Xiaohong Tan; Hongwei Zhang; Carlo Visco; Alexandar Tzankov; Karen Dybkaer; Govind Bhagat; Wayne Tam; Hua You; Eric D Hsi; J Han van Krieken; Jooryung Huh; Maurilio Ponzoni; Andrés J M Ferreri; Michael B Møller; Miguel A Piris; Jane N Winter; Jeffrey T Medeiros; Bing Xu; Yong Li; Ilan Kirsch; Ken H Young
Journal:  J Immunother Cancer       Date:  2019-10-22       Impact factor: 13.751
  6 in total

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