Literature DB >> 12039582

Drugs, leads, and drug-likeness: an analysis of some recently launched drugs.

John R Proudfoot1.   

Abstract

An analysis of the origins of recently launched drugs reveals that most were derived by modification of known drug structures or from lead structures obtained from the scientific literature. High-throughput screening did not have a significant impact on the derivation of these drugs. The drug structures are very closely related to their leads.

Mesh：

Year:  2002        PMID： 12039582     DOI： 10.1016/s0960-894x(02)00244-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  24 in total

1.  Leadlikeness and structural diversity of synthetic screening libraries.

Authors:  Herman J Verheij
Journal:  Mol Divers       Date:  2006-09-21       Impact factor: 2.943

2.  Lead-like, drug-like or "Pub-like": how different are they?

Authors:  Tudor I Oprea; Tharun Kumar Allu; Dan C Fara; Ramona F Rad; Lili Ostopovici; Cristian G Bologa
Journal:  J Comput Aided Mol Des       Date:  2007-02-28       Impact factor: 3.686

Review 3.  The influence of lead discovery strategies on the properties of drug candidates.

Authors:  György M Keserü; Gergely M Makara
Journal:  Nat Rev Drug Discov       Date:  2009-03       Impact factor: 84.694

Review 4.  On a biophysical and mathematical model of Pgp-mediated multidrug resistance: understanding the "space-time" dimension of MDR.

Authors:  Vasiliki Panagiotopoulou; Giles Richardson; Oliver E Jensen; Cyril Rauch
Journal:  Eur Biophys J       Date:  2009-11-04       Impact factor: 1.733

Review 5.  Toward Small-Molecule Inhibition of Protein-Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions.

Authors:  Damir Bojadzic; Peter Buchwald
Journal:  Curr Top Med Chem       Date:  2018       Impact factor: 3.295

Review 6.  Nitroso Diels-Alder (NDA) reaction as an efficient tool for the functionalization of diene-containing natural products.

Authors:  Serena Carosso; Marvin J Miller
Journal:  Org Biomol Chem       Date:  2014-10-14       Impact factor: 3.876

7.  Molecular docking, PASS analysis, bioactivity score prediction, synthesis, characterization and biological activity evaluation of a functionalized 2-butanone thiosemicarbazone ligand and its complexes.

Authors:  Tahmeena Khan; Shalini Dixit; Rumana Ahmad; Saman Raza; Iqbal Azad; Seema Joshi; Abdul Rahman Khan
Journal:  J Chem Biol       Date:  2017-04-04

8.  Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores.

Authors:  Iwona E Weidlich; Thomas Dexheimer; Christophe Marchand; Smitha Antony; Yves Pommier; Marc C Nicklaus
Journal:  Bioorg Med Chem       Date:  2009-11-11       Impact factor: 3.641

9.  The pK(a) Distribution of Drugs: Application to Drug Discovery.

Authors:  David T Manallack
Journal:  Perspect Medicin Chem       Date:  2007-09-17

10.  Virtual screening for oseltamivir-resistant a (H5N1) influenza neuraminidase from traditional Chinese medicine database: a combined molecular docking with molecular dynamics approach.

Authors:  Vasudevan Karthick; Karuppasamy Ramanathan
Journal:  Springerplus       Date:  2013-03-18
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