Literature DB >> 12039569

Discovery and evaluation of N-(triazin-1,3,5-yl) phenylalanine derivatives as VLA-4 integrin antagonists.

John R Porter1, Sarah C Archibald, Julien A Brown, Kirstie Childs, David Critchley, John C Head, Brian Hutchinson, Ted A H Parton, Martyn K Robinson, Anthony Shock, Graham J Warrellow, Alex Zomaya.   

Abstract

SAR studies aimed at improving the rate of clearance of a series of VLA-4 integrin antagonists by the introduction of a 1,3,5-triazine as an amide isostere are described.

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Year:  2002        PMID： 12039569     DOI： 10.1016/s0960-894x(02)00237-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  An integrated QSAR modeling approach to explore the structure-property and selectivity relationships of N-benzoyl-L-biphenylalanines as integrin antagonists.

Authors:  Sk Abdul Amin; Nilanjan Adhikari; Sonam Bhargava; Shovanlal Gayen; Tarun Jha
Journal:  Mol Divers       Date:  2017-11-17       Impact factor: 2.943

2.  Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity.

Authors:  Khadijah M Al-Zaydi; Hosam H Khalil; Ayman El-Faham; Sherine N Khattab
Journal:  Chem Cent J       Date:  2017-05-10       Impact factor: 4.215

3.  Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors.

Authors:  Sherine N Khattab; Hosam H Khalil; Adnan A Bekhit; Mohamed Mokbel Abd El-Rahman; Ayman El-Faham; Fernando Albericio
Journal:  Molecules       Date:  2015-09-02       Impact factor: 4.411
  3 in total

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