| Literature DB >> 12036352 |
Judit Hohmann1, Joseph Molnár, Dóra Rédei, Ferenc Evanics, Peter Forgo, Alajos Kálmán, Gyula Argay, Pál Szabó.
Abstract
The effects of 15 jatrophane diterpene polyesters (1-3 and 5-16) isolated from lipophilic extracts of Euphorbia serrulata, E. esula, E. salicifolia, and E. peplus (Euphorbiaceae) on the reversion of multidrug resistance of mouse lymphoma cells were examined. The structures of five new compounds (1-5) were elucidated by spectroscopic methods, including HRFABMS, ESIMS, (1)H-(1)H homonuclear and (1)H-(13)C heteronuclear correlations, long-range correlation spectra, and NOESY experiments. The stereochemistry and absolute configuration of one compound (3) were determined by X-ray crystallography. The structure-activity relationship is discussed.Entities:
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Year: 2002 PMID： 12036352 DOI： 10.1021/jm0111301
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446