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Literature DB >> 12034817

Tiny telomere DNA.

Jinsong Ren¹, Xiaogang Qu, John O Trent, Jonathan B Chaires.

Abstract

We describe the design, synthesis and biophysical characterization of a novel DNA construct in which a folded quadruplex structure is joined to a standard double helix. Circular dichroism, gel electrophoresis, three-dimensional UV melting and differential scanning calorimetry were all used to characterize the structure. Rigorous molecular dynamics simulations were used to build a plausible atomic-level structural model of the DNA construct. This novel DNA construct provides a model for the duplex-quadruplex junction region at the end of chromosomal DNA and offers a system for the study of structure-selective ligand binding.

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Substances：

Year: 2002 PMID： 12034817 PMCID： PMC117210 DOI： 10.1093/nar/30.11.2307

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

38 in total

Review 1. Functional and dysfunctional roles of quadruplex DNA in cells.

Authors: H Arthanari; P H Bolton
Journal: Chem Biol Date: 2001-03

2. A DNA pentaplex incorporating nucleobase quintets.

Authors: J C Chaput; C Switzer
Journal: Proc Natl Acad Sci U S A Date: 1999-09-14 Impact factor: 11.205

3. An intramolecular quadruplex of (GGA)(4) triplet repeat DNA with a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad, and its dimeric interaction.

Authors: A Matsugami; K Ouhashi; M Kanagawa; H Liu; S Kanagawa; S Uesugi; M Katahira
Journal: J Mol Biol Date: 2001-10-19 Impact factor: 5.469

4. V-shaped scaffold: a new architectural motif identified in an A x (G x G x G x G) pentad-containing dimeric DNA quadruplex involving stacked G(anti) x G(anti) x G(anti) x G(syn) tetrads.

Authors: N Zhang; A Gorin; A Majumdar; A Kettani; N Chernichenko; E Skripkin; D J Patel
Journal: J Mol Biol Date: 2001-08-31 Impact factor: 5.469

Review 5. Molecular modeling of drug-DNA complexes: an update.

Authors: J O Trent
Journal: Methods Enzymol Date: 2001 Impact factor: 1.600

6. Solution structure of an A-tract DNA bend.

Authors: D MacDonald; K Herbert; X Zhang; T Pologruto; P Lu; T Polgruto
Journal: J Mol Biol Date: 2001-03-09 Impact factor: 5.469

7. Transmission of stability (telestability) in deoxyribonucleic acid. Physical and enzymatic studies on the duplex block polymer d(C15A15) - d(T15G15).

Authors: J F Burd; R M Wartell; J B Dodgson; R D Wells
Journal: J Biol Chem Date: 1975-07-10 Impact factor: 5.157

8. Further studies on telestability in DNA. The synthesis and characterization of the duplex block polymers d(C20A10) - d(T10G20) and d(C20A15) - d(T15G20).

Authors: J F Burd; J E Larson; R D Wells
Journal: J Biol Chem Date: 1975-08-10 Impact factor: 5.157

9. Cleavage of telomeric G-quadruplex DNA with perylene-EDTA*Fe(II).

Authors: W Tuntiwechapikul; M Salazar
Journal: Biochemistry Date: 2001-11-13 Impact factor: 3.162

10. High resolution proton nuclear magnetic resonance investigation of the structural and dynamic properties of d(C15A15)-d(T15G15).

Authors: T A Early; D R Kearns; J F Burd; J E Larson; R D Wells
Journal: Biochemistry Date: 1977-02-08 Impact factor: 3.162

27 in total

1. Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix.

Authors: Anh Tuân Phan; Jean-Louis Mergny
Journal: Nucleic Acids Res Date: 2002-11-01 Impact factor: 16.971

2. Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer.

Authors: Liming Ying; Jeremy J Green; Haitao Li; David Klenerman; Shankar Balasubramanian
Journal: Proc Natl Acad Sci U S A Date: 2003-11-25 Impact factor: 11.205

3. Intramolecular quadruplex conformation of human telomeric DNA assessed with 125I-radioprobing.

Authors: Yujian He; Ronald D Neumann; Igor G Panyutin
Journal: Nucleic Acids Res Date: 2004-10-08 Impact factor: 16.971

4. Carboxyl-modified single-walled carbon nanotubes selectively induce human telomeric i-motif formation.

Authors: Xi Li; Yinghua Peng; Jinsong Ren; Xiaogang Qu
Journal: Proc Natl Acad Sci U S A Date: 2006-12-13 Impact factor: 11.205

5. Small-molecule selectively recognizes human telomeric G-quadruplex DNA and regulates its conformational switch.

Authors: Mingli Chen; Guangtao Song; Chunyan Wang; Dan Hu; Jinsong Ren; Xiaogang Qu
Journal: Biophys J Date: 2009-10-07 Impact factor: 4.033

6. The 3D structures of G-quadruplexes of HIV-1 integrase inhibitors: molecular dynamics simulations in aqueous solution and in the gas phase.

Authors: Ming-Hui Li; Yi-Han Zhou; Quan Luo; Ze-Sheng Li
Journal: J Mol Model Date: 2009-10-04 Impact factor: 1.810