| Literature DB >> 12032777 |
Dan A Liebermann1, Barbara Hoffman.
Abstract
Myeloid Differentiation (MyD) primary response and Growth Arrest DNA-Damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45alpha MyD118/Gadd45beta, GADD45gamma, MyD116/Gadd34) genes, that have been cloned by virtue of there being co-ordinately induced upon the onset of terminal myeloid differentiation. This review delineates the role MyD genes play in blood cell development, where they function as positive regulators of terminal differentiation, lineage specific blood cell development and control of blood cell homeostasis, including growth inhibition and apoptosis.Entities:
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Year: 2002 PMID: 12032777 DOI: 10.1038/sj.onc.1205312
Source DB: PubMed Journal: Oncogene ISSN: 0950-9232 Impact factor: 9.867