Literature DB >> 12027768

Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891.

Carmen Méndez1, Eva Künzel, Fredilyn Lipata, Felipe Lombó, William Cotham, Michael Walla, Daniel W Bearden, Alfredo F Braña, Jose A Salas, Jürgen Rohr.   

Abstract

Our investigations on the discovery of novel natural metabolites using type II polyketide synthase gene probes (actI/III) yielded an unusual angucyclinone, oviedomycin (2), when applied to the oleandomycin (1) producer Streptomyces antibioticus ATCC11891. The novel natural product was produced using S. albus R(-)M(-) as a host strain, into which a cosmid containing the oviedomycin gene cluster was transformed. Its structure was elucidated by NMR spectroscopy and mass spectrometry.

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Year:  2002        PMID： 12027768     DOI： 10.1021/np010555n

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

1.  Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002.

Authors:  Mohamed S Abdelfattah; Madan Kumar Kharel; John Andrew Hitron; Irfan Baig; Jürgen Rohr
Journal:  J Nat Prod       Date:  2008-07-31       Impact factor: 4.050

2.  Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity.

Authors:  Felipe Lombó; Mohamed S Abdelfattah; Alfredo F Braña; José A Salas; Jürgen Rohr; Carmen Méndez
Journal:  Chembiochem       Date:  2009-01-26       Impact factor: 3.164

3.  Activation and mechanism of a cryptic oviedomycin gene cluster via the disruption of a global regulatory gene, adpA, in Streptomyces ansochromogenes.

Authors:  Jingjing Xu; Jihui Zhang; Jiming Zhuo; Yue Li; Yuqing Tian; Huarong Tan
Journal:  J Biol Chem       Date:  2017-09-25       Impact factor: 5.157

Review 4.  Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.

Authors:  Carlos Olano; Carmen Méndez; José A Salas
Journal:  Microb Biotechnol       Date:  2010-11-18       Impact factor: 5.813

Review 5.  Two-component systems in Streptomyces: key regulators of antibiotic complex pathways.

Authors:  Héctor Rodríguez; Sergio Rico; Margarita Díaz; Ramón I Santamaría
Journal:  Microb Cell Fact       Date:  2013-12-19       Impact factor: 5.328

6.  Nocardiopsistins A-C: New angucyclines with anti-MRSA activity isolated from a marine sponge-derived Nocardiopsis sp. HB-J378.

Authors:  Dongbo Xu; Keshav K Nepal; Jing Chen; Dedra Harmody; Haining Zhu; Peter J McCarthy; Amy E Wright; Guojun Wang
Journal:  Synth Syst Biotechnol       Date:  2018-11-02

7.  Attempted characterisation of phenanthrene-4,5-quinone and electrochemical synthesis of violanthrone-16,17-quinone. How does the stability of bay quinones correlate with structural and electronic parameters?

Authors:  Dylan Wilkinson; Giacomo Cioncoloni; Mark D Symes; Götz Bucher
Journal:  RSC Adv       Date:  2020-10-15       Impact factor: 3.361

8.  Regulation of the AbrA1/A2 two-component system in Streptomyces coelicolor and the potential of its deletion strain as a heterologous host for antibiotic production.

Authors:  Sergio Rico; Ana Yepes; Héctor Rodríguez; Jorge Santamaría; Sergio Antoraz; Eva M Krause; Margarita Díaz; Ramón I Santamaría
Journal:  PLoS One       Date:  2014-10-10       Impact factor: 3.240
  8 in total

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