Literature DB >> 12023364

A three-megabase yeast artificial chromosome contig spanning the C57BL mouse Igh locus.

Christophe Chevillard1, Jennifer Ozaki, Christopher D Herring, Roy Riblet.   

Abstract

The mouse Ig H chain (Igh) complex locus is composed of >100 gene segments encoding the variable, diversity, joining, and constant portions of the Ab H chain protein. To advance the characterization of this locus and to identify all the V(H) genes, we have isolated the entire region from C57BL/6 and C57BL/10 as a yeast artificial chromosome contig. The mouse Igh locus extends approximately three megabases and contains at least 134 V(H) genes classified in 15 partially interspersed families. Two non-Igh pseudogenes (Odc-rs8 and Rpl32-rs14) were localized in the distal part of the locus. This physical yeast artificial chromosome map will provide important structure and guidance for the sequencing of this large, complex, and highly repetitive locus.

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Year:  2002        PMID： 12023364     DOI： 10.4049/jimmunol.168.11.5659

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  16 in total

1.  Replication and subnuclear location dynamics of the immunoglobulin heavy-chain locus in B-lineage cells.

Authors:  Jie Zhou; Olga V Ermakova; Roy Riblet; Barbara K Birshtein; Carl L Schildkraut
Journal:  Mol Cell Biol       Date:  2002-07       Impact factor: 4.272

2.  Changes in histone acetylation are associated with differences in accessibility of V(H) gene segments to V-DJ recombination during B-cell ontogeny and development.

Authors:  Kristen Johnson; Cristina Angelin-Duclos; Sinae Park; Kathryn L Calame
Journal:  Mol Cell Biol       Date:  2003-04       Impact factor: 4.272

3.  Sequence and characterization of the Ig heavy chain constant and partial variable region of the mouse strain 129S1.

Authors:  Ida Retter; Christophe Chevillard; Maren Scharfe; Ansgar Conrad; Martin Hafner; Tschong-Hun Im; Monika Ludewig; Gabriele Nordsiek; Simone Severitt; Stephanie Thies; America Mauhar; Helmut Blöcker; Werner Müller; Roy Riblet
Journal:  J Immunol       Date:  2007-08-15       Impact factor: 5.422

4.  Epigenetic modifications of the VH region after DJH recombination in Pro-B cells.

Authors:  Yanying Dong; Caijun Wu; Xiaohui Zhao; Ping Zhang; Hua Zhang; Mingzhe Zheng; Shichang Li; Junna Jiao; Xiaozhuo Yu; Zhuangwei Lv; Yanhong Ji
Journal:  Immunology       Date:  2017-06-23       Impact factor: 7.397

5.  S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.

Authors:  Robert Wuerffel; Lili Wang; Fernando Grigera; John Manis; Erik Selsing; Thomas Perlot; Frederick W Alt; Michel Cogne; Eric Pinaud; Amy L Kenter
Journal:  Immunity       Date:  2007-11-01       Impact factor: 31.745

6.  Molecular evolution of V(H)9 germline genes isolated from DBA, BALB, 129 and C57BL mouse strains and sublines.

Authors:  Paula Zylstra; Andrew Franklin; Karl A Hassan; Kim L Powell; Edward J Steele; Robert V Blanden
Journal:  Immunogenetics       Date:  2003-05-06       Impact factor: 2.846

7.  The immunoglobulin IGHD gene locus in C57BL/6 mice.

Authors:  Jian Ye
Journal:  Immunogenetics       Date:  2004-08-18       Impact factor: 2.846

8.  Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene.

Authors:  Martin Fuxa; Jane Skok; Abdallah Souabni; Giorgia Salvagiotto; Esther Roldan; Meinrad Busslinger
Journal:  Genes Dev       Date:  2004-02-15       Impact factor: 11.361

9.  Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments.

Authors:  David G T Hesslein; David L Pflugh; Dipanjan Chowdhury; Alfred L M Bothwell; Ranjan Sen; David G Schatz
Journal:  Genes Dev       Date:  2003-01-01       Impact factor: 11.361

10.  A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation.

Authors:  Tirtha Chakraborty; Thomas Perlot; Ramesh Subrahmanyam; Anant Jani; Peter H Goff; Yu Zhang; Irina Ivanova; Frederick W Alt; Ranjan Sen
Journal:  J Exp Med       Date:  2009-05-04       Impact factor: 14.307
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