Literature DB >> 12020801

Polycomb repression: from cellular memory to cellular proliferation and cancer.

Jacqueline J L Jacobs1, Maarten van Lohuizen.   

Abstract

The transcriptional repressors of the Polycomb group (PcG), together with the counteracting Trithorax group (TrxG) proteins, establish a form of cellular memory by regulating gene expression in a heritable fashion at the level of chromatin. This cellular memory function is required for a correct cell fate/behavior, which is not only crucial during development for the generation of a correct body plan but also later in life to prevent cellular transformation. Here, we summarize the rapidly accumulating data that implicate several mammalian PcG members in the control of cellular proliferation and tumorigenesis.

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Year:  2002        PMID： 12020801     DOI： 10.1016/s0304-419x(02)00052-5

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  81 in total

1.  Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.

Authors:  Anna V Molofsky; Ricardo Pardal; Toshihide Iwashita; In-Kyung Park; Michael F Clarke; Sean J Morrison
Journal:  Nature       Date:  2003-10-22       Impact factor: 49.962

2.  A proposed role for the Polycomb group protein dRING in meiotic sister-chromatid cohesion.

Authors:  Eric M Balicky; Lynn Young; Terry L Orr-Weaver; Sharon E Bickel
Journal:  Chromosoma       Date:  2003-12-11       Impact factor: 4.316

3.  Site-specific expression of polycomb-group genes encoding the HPC-HPH/PRC1 complex in clinically defined primary nodal and cutaneous large B-cell lymphomas.

Authors:  Frank M Raaphorst; Maarten Vermeer; Elly Fieret; Tjasso Blokzijl; Danny Dukers; Richard G A B Sewalt; Arie P Otte; Rein Willemze; Chris J L M Meijer
Journal:  Am J Pathol       Date:  2004-02       Impact factor: 4.307

Review 4.  Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins.

Authors:  Alea A Mills
Journal:  Nat Rev Cancer       Date:  2010-10       Impact factor: 60.716

5.  The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane.

Authors:  Matthew L Fisher; Gautam Adhikary; Dan Grun; David M Kaetzel; Richard L Eckert
Journal:  Mol Carcinog       Date:  2015-12-23       Impact factor: 4.784

6.  Novel role of the RET finger protein in estrogen receptor-mediated transcription in MCF-7 cells.

Authors:  Steven M Townson; Kaiyan Kang; Adrian V Lee; Steffi Oesterreich
Journal:  Biochem Biophys Res Commun       Date:  2006-08-22       Impact factor: 3.575

7.  The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.

Authors:  Stuart S Levine; Alona Weiss; Hediye Erdjument-Bromage; Zhaohui Shao; Paul Tempst; Robert E Kingston
Journal:  Mol Cell Biol       Date:  2002-09       Impact factor: 4.272

Review 8.  Role of chromatin states in transcriptional memory.

Authors:  Sharmistha Kundu; Craig L Peterson
Journal:  Biochim Biophys Acta       Date:  2009-02-21

9.  The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival.

Authors:  Sivaprakasam Balasubramanian; Gautam Adhikary; Richard L Eckert
Journal:  Carcinogenesis       Date:  2009-12-16       Impact factor: 4.944

10.  Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.

Authors:  Diego Pasini; Adrian P Bracken; Michael R Jensen; Eros Lazzerini Denchi; Kristian Helin
Journal:  EMBO J       Date:  2004-09-23       Impact factor: 11.598
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