SETTING: An academic hospital in the Western Cape, South Africa. OBJECTIVE: To evaluate cytokine production (interferon-gamma [IFN-gamma], interleukin-1 [IL-1], interleukin-2 [IL-2], interleukin-6 [IL-6], interleukin-10 [IL-10], interleukin-4 [IL-4] and tumour necrosis factor-alpha [TNF-alpha]) in patients with tuberculous pericarditis. DESIGN: Subpopulation of a consecutive prospective case series. PATIENTS: Thirty patients presenting with pericardial effusions due to tuberculosis (n = 19), malignancy (n = 6) and non-tuberculous infections (n = 5), and five control subjects who had undergone open heart surgery. RESULTS: The concentration of IFN-gamma was significantly higher in tuberculous pericardial effusions than in the other diagnostic classes (P < 0.0005). The concentration of TNF-alpha was similar in both infective and tuberculous effusions, but was significantly higher than that of malignant effusions. IL-1 and IL-2 were undetectable in malignant effusions, but elevated in both infective and tuberculous pericardial effusions. The levels of IL-1 and IL-2 were furthermore significantly higher in pericardial effusions due to infective compared to tuberculous causes. The concentration of IL-6, while elevated in all diagnostic classes, was significantly higher in the malignant group. Elevated levels of IL-10 and undetectable levels of IL-4 were observed in all three diagnostic groups. CONCLUSION: These findings suggest that tuberculous pericardial effusions arise due to a hypersensitivity reaction that is orchestrated by the TH-1 lymphocytes.
SETTING: An academic hospital in the Western Cape, South Africa. OBJECTIVE: To evaluate cytokine production (interferon-gamma [IFN-gamma], interleukin-1 [IL-1], interleukin-2 [IL-2], interleukin-6 [IL-6], interleukin-10 [IL-10], interleukin-4 [IL-4] and tumour necrosis factor-alpha [TNF-alpha]) in patients with tuberculous pericarditis. DESIGN: Subpopulation of a consecutive prospective case series. PATIENTS: Thirty patients presenting with pericardial effusions due to tuberculosis (n = 19), malignancy (n = 6) and non-tuberculous infections (n = 5), and five control subjects who had undergone open heart surgery. RESULTS: The concentration of IFN-gamma was significantly higher in tuberculous pericardial effusions than in the other diagnostic classes (P < 0.0005). The concentration of TNF-alpha was similar in both infective and tuberculous effusions, but was significantly higher than that of malignant effusions. IL-1 and IL-2 were undetectable in malignant effusions, but elevated in both infective and tuberculous pericardial effusions. The levels of IL-1 and IL-2 were furthermore significantly higher in pericardial effusions due to infective compared to tuberculous causes. The concentration of IL-6, while elevated in all diagnostic classes, was significantly higher in the malignant group. Elevated levels of IL-10 and undetectable levels of IL-4 were observed in all three diagnostic groups. CONCLUSION: These findings suggest that tuberculous pericardial effusions arise due to a hypersensitivity reaction that is orchestrated by the TH-1 lymphocytes.
Authors: Kerryn Matthews; Armin Deffur; Mpiko Ntsekhe; Faisal Syed; James B W Russell; Kemi Tibazarwa; Janine Wolske; Johan Brink; Bongani M Mayosi; Robert J Wilkinson; Katalin A Wilkinson Journal: Am J Respir Crit Care Med Date: 2015-12-15 Impact factor: 21.405
Authors: Giovanni Porta; Fabio G Numis; Valerio Rosato; Antonio Pagano; Mario Masarone; Giorgio Bosso; Claudia Serra; Luca Rinaldi; Maria C Fascione; Annalisa Amelia; Fiorella Paladino; Fernando Schiraldi Journal: Intern Emerg Med Date: 2017-09-30 Impact factor: 3.397
Authors: Kerryn Matthews; Katalin A Wilkinson; Barbara Kalsdorf; Teri Roberts; Andreas Diacon; Gerhard Walzl; Janine Wolske; Mpiko Ntsekhe; Faisal Syed; James Russell; Bongani M Mayosi; Rodney Dawson; Keertan Dheda; Robert J Wilkinson; Willem A Hanekom; Thomas J Scriba Journal: Tuberculosis (Edinb) Date: 2011-07-20 Impact factor: 3.131
Authors: Mpiko Ntsekhe; Kerryn Matthews; Faisal F Syed; Armin Deffur; Motasim Badri; Patrick J Commerford; Bernard J Gersh; Katalin A Wilkinson; Robert J Wilkinson; Bongani M Mayosi Journal: PLoS One Date: 2013-10-14 Impact factor: 3.240
Authors: Thomas J Scriba; Adam Penn-Nicholson; Smitha Shankar; Tom Hraha; Ethan G Thompson; David Sterling; Elisa Nemes; Fatoumatta Darboe; Sara Suliman; Lynn M Amon; Hassan Mahomed; Mzwandile Erasmus; Wendy Whatney; John L Johnson; W Henry Boom; Mark Hatherill; Joe Valvo; Mary Ann De Groote; Urs A Ochsner; Alan Aderem; Willem A Hanekom; Daniel E Zak Journal: PLoS Pathog Date: 2017-11-16 Impact factor: 6.823