OBJECTIVE: This study examined the effects of oral estrogen (ERT) alone versus oral estrogen/medroxyprogesterone acetate (HRT) therapy on cardiovascular function, as controlled by the autonomic nervous system. STUDY DESIGN:Forty-three postmenopausal women receivedERT, HRT, or a placebo for 3 months in a double-blind, randomized, placebo-controlled study. Cardiovascular hemodynamics and heart rate variability were assessed at rest and during stress. RESULTS: After 3 months of therapy, oral HRT significantly increased high-frequency power (P =.0002) and decreased total peripheral resistance (P =.04). The changes were evident at rest and during stress. CONCLUSION: Our findings suggest that combination therapy produces a more favorable alteration of autonomic cardiovascular function than estrogen alone (ie, combination therapy increases vagal activity).
RCT Entities:
OBJECTIVE: This study examined the effects of oral estrogen (ERT) alone versus oral estrogen/medroxyprogesterone acetate (HRT) therapy on cardiovascular function, as controlled by the autonomic nervous system. STUDY DESIGN: Forty-three postmenopausal women received ERT, HRT, or a placebo for 3 months in a double-blind, randomized, placebo-controlled study. Cardiovascular hemodynamics and heart rate variability were assessed at rest and during stress. RESULTS: After 3 months of therapy, oral HRT significantly increased high-frequency power (P =.0002) and decreased total peripheral resistance (P =.04). The changes were evident at rest and during stress. CONCLUSION: Our findings suggest that combination therapy produces a more favorable alteration of autonomic cardiovascular function than estrogen alone (ie, combination therapy increases vagal activity).
Authors: Richard P Sloan; Peter A Shapiro; Ronald E DeMeersman; Emilia Bagiella; Elizabeth N Brondolo; Paula S McKinley; Iordan Slavov; Yixin Fang; Michael M Myers Journal: Am J Public Health Date: 2009-03-19 Impact factor: 9.308
Authors: Irina W Neufeld; Anton R Kiselev; Antoly S Karavaev; Mikhail D Prokhorov; Vladimir I Gridnev; Vladimir I Ponomarenko; Boris P Bezruchko Journal: J Turk Ger Gynecol Assoc Date: 2015-03-01
Authors: Elizabeth A Jackson; Samar R El Khoudary; Sybil L Crawford; Karen Matthews; Hadine Joffe; Claudia Chae; Rebecca C Thurston Journal: J Womens Health (Larchmt) Date: 2016-07-12 Impact factor: 2.681
Authors: Paula S McKinley; Arlene R King; Peter A Shapiro; Iordan Slavov; Yixin Fang; Ivy S Chen; Larry D Jamner; Richard P Sloan Journal: Psychophysiology Date: 2009-04-06 Impact factor: 4.016
Authors: Anton R Kiselev; Irina W Neufeld; Irina V Bobyleva; Mikhail D Prokhorov; Anatoly S Karavaev Journal: Cardiovasc Endocrinol Metab Date: 2018-08-15