Hongbo Zhai1, Howard I Maibach. 1. Department of Dermatology, University of California, School of Medicine, San Francisco 94143-0989, USA.
Abstract
BACKGROUND/AIMS: Skin occlusion may increase percutaneous absorption of applied chemicals, with some exceptions. It also obstructs the normal ventilation of the skin surface and increases stratum corneum hydration and hence compromises skin barrier function. METHODS/ RESULTS: This review focuses the effects of occlusion on skin barrier function, in particularly, as defined with objective skin bioengineering technology. CONCLUSIONS: The effects of occlusion on skin barrier function have been defined with various techniques. Optimal hydrocolloid materials can absorb excess water and reduce the unfavourable effects of occlusion.
BACKGROUND/AIMS: Skin occlusion may increase percutaneous absorption of applied chemicals, with some exceptions. It also obstructs the normal ventilation of the skin surface and increases stratum corneum hydration and hence compromises skin barrier function. METHODS/ RESULTS: This review focuses the effects of occlusion on skin barrier function, in particularly, as defined with objective skin bioengineering technology. CONCLUSIONS: The effects of occlusion on skin barrier function have been defined with various techniques. Optimal hydrocolloid materials can absorb excess water and reduce the unfavourable effects of occlusion.
Authors: Johan du Plessis; Aleksandr Stefaniak; Fritz Eloff; Swen John; Tove Agner; Tzu-Chieh Chou; Rosemary Nixon; Markus Steiner; Anja Franken; Irena Kudla; Linn Holness Journal: Skin Res Technol Date: 2013-01-19 Impact factor: 2.365
Authors: Varuni R Brownhill; Elizabeth Huddleston; Andrea Bell; Jeffrey Hart; Iain Webster; Matthew J Hardman; Holly N Wilkinson Journal: Adv Wound Care (New Rochelle) Date: 2020-11-13 Impact factor: 4.730