Literature DB >> 1200028

A G gamma type of the hereditary persistence of fetal hemoglobin with beta chain production in cis.

T H Huisman, A Miller, W A Schroeder.   

Abstract

In a new subclass of G gamma HPFH which has been detected in a black family, beta A chains are produced in cis to the HPFH determinant (the G gamma-beta+ HPFH). No other instance of beta chain production in cis to HPFH has been reported. All individuals in this family are well even if Hb S is produced in trans to HPFH. Genetically, this new subclass requires a slightly smaller deletion in the gamma, delta, and beta complex of genes than do other forms of HPFH. It is speculated that a subclass (the G gamma-(G gamma A gamma)-beta+ HPFH) in which beta S chains are produced in cis to HPFH in conjunction with true beta S genes in trans may be responsible for "mild" cases of sickle cell anemia.

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Year:  1975        PMID： 1200028      PMCID： PMC1762888     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  21 in total

1.  The homozygous state of persistent fetal hemoglobin and the interaction of persistent fetal hemoglobin with thalassemia.

Authors:  J T WHEELER; J R KREVANS
Journal:  Bull Johns Hopkins Hosp       Date:  1961-11

2.  Microchromatography of hemoglobins. II. A rapid method for the determination of hemoglobin A2.

Authors:  C D Efremov; T H Huisman; K Bowman; R N Wrightstone; W A Shroeder
Journal:  J Lab Clin Med       Date:  1974-04

3.  Unbalanced globin chain synthesis in reticulocytes of sickle cell trait individuals with low concentrations of hemoglobin S.

Authors:  J DeSimone; L Kleve; M A Longley; J Shaeffer
Journal:  Biochem Biophys Res Commun       Date:  1974-07-24       Impact factor: 3.575

4.  A homozygote for the Hb G type of foetal haemoglobin in India: a study of two Indian and four Negro families.

Authors:  P K Sukumaran; T H Huisman; W A Schroeder; P R McCurdy; J T Freehafer; N Bouver; J R Shelton; J B Shelton; G Apell
Journal:  Br J Haematol       Date:  1972-10       Impact factor: 6.998

5.  Chemical heterogeneity of fetal hemoglobin in subjects with sickle cell anemia, homozygous Hb-C disease, SC disease, and various combinations of hemoglobin variants.

Authors:  T H Huisman; W A Schroeder; N G Bouver; A Miller; J R Shelton; J B Shelton; G Apell
Journal:  Clin Chim Acta       Date:  1972-04       Impact factor: 3.786

6.  Studies on the heterogeneity of hemoglobin. 13. Chromatography of various human and animal hemoglobin types on DEAE-Sephadex.

Authors:  A M Dozy; E F Kleihauer; T H Huisman
Journal:  J Chromatogr       Date:  1968-02-20

7.  An improved method for quantitative determination of human fetal hemoglobin.

Authors:  W A Schroeder; T H Huisman; J R Shelton; J B Wilson
Journal:  Anal Biochem       Date:  1970-05       Impact factor: 3.365

8.  An adult homozygous for persistent fetal hemoglobin.

Authors:  W Siegel; R Cox; W Schroeder; T H Huisman; O Penner; P T Rowley
Journal:  Ann Intern Med       Date:  1970-04       Impact factor: 25.391

Review 9.  Normal and abnormal human hemoglobins.

Authors:  T H Huisman
Journal:  Adv Clin Chem       Date:  1972       Impact factor: 5.394

10.  A Ghanaian adult, homozygous for hereditary persistence of foetal haemoglobin and heterozygous for elliptocytosis.

Authors:  B Ringelhann; F I Konotey-Ahulu; H Lehmann; P A Lorkin
Journal:  Acta Haematol       Date:  1970       Impact factor: 2.195
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  8 in total

1.  The chemical heterogeneity of the fetal hemoglobin in normal newborn infants and in adults.

Authors:  T H Huisman; H Harris; M Gravely
Journal:  Mol Cell Biochem       Date:  1977-08-19       Impact factor: 3.396

2.  Inheritance of F cell frequency in heterocellular hereditary persistence of fetal hemoglobin: an example of allelic exclusion.

Authors:  S H Boyer; L Margolet; M L Boyer; T H Huisman; W A Schroeder; W G Wood; D J Weatherall; J B Clegg; R Cartner
Journal:  Am J Hum Genet       Date:  1977-05       Impact factor: 11.025

3.  Interaction of alpha- and delta beta o- thalassaemia: haematological features and globin chain synthesis analysis.

Authors:  R Galanello; M Furbetta; M A Melis; C Rosatelli; A Cao
Journal:  J Med Genet       Date:  1981-02       Impact factor: 6.318

4.  Restriction endonuclease mapping of gamma-delta-beta-globin region in G gamma (beta)+ HPFH and a Chinese A gamma HPFH variant.

Authors:  M Farquhar; R Gelinas; B Tatsis; J Murray; M Yagi; R Mueller; G Stamatoyannopoulos
Journal:  Am J Hum Genet       Date:  1983-07       Impact factor: 11.025

5.  Heterogeneity of sickle-cell anemia based on a profile of hematological variables.

Authors:  D J Odenheimer; C F Whitten; D L Rucknagel; S A Sarnaik; C F Sing
Journal:  Am J Hum Genet       Date:  1983-11       Impact factor: 11.025

Review 6.  The thalassemias: molecular mechanisms of human genetic disease.

Authors:  R A Spritz; B G Forget
Journal:  Am J Hum Genet       Date:  1983-05       Impact factor: 11.025

7.  G gamma beta + type of hereditary persistence of fetal haemoglobin in association with Hb C.

Authors:  D R Higgs; J B Clegg; W G Wood; D J Weatherall
Journal:  J Med Genet       Date:  1979-08       Impact factor: 6.318

8.  G gamma delta beta thalassaemia and g gamma HPFH (Hb Kenya type): comparison of 2 new cases.

Authors:  W G Wood; J B Clegg; D J Weatherall; O H Gyde; D A Obeid; M J Tarlow; M J Brown; S Hewitt
Journal:  J Med Genet       Date:  1977-08       Impact factor: 6.318
  8 in total

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