| Literature DB >> 11994445 |
Toufic Renno1, Anne Wilson, Caroline Dunkel, Isabelle Coste, Karine Maisnier-Patin, Amélie Benoit de Coignac, Jean-Pierre Aubry, Rosemary K Lees, Jean-Yves Bonnefoy, H Robson MacDonald, Jean-François Gauchat.
Abstract
We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCRbeta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.Entities:
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Year: 2002 PMID: 11994445 DOI: 10.4049/jimmunol.168.10.4946
Source DB: PubMed Journal: J Immunol ISSN: 0022-1767 Impact factor: 5.422