Literature DB >> 11990865

Selective suppression of chemokine receptor CXCR3 expression by interferon-beta1a in multiple sclerosis.

T L Sørensen1, F Sellebjerg.   

Abstract

We studied the expression of chemokine receptors CCR1, CCR2, CCR3, CCR5, and CXCR3 on CD4 and CD8 positive T cells, and on CD14 positive monocytes in blood from 10 patients with relapsing-remitting multiple sclerosis (MS) at initiation of interferon (IFN)-beta treatment, after 1 month and after 3 months of treatment. It was found that the expression of CXCR3 on CD4+ and CD8+ T cells was significantly reduced after 3 months of treatment. The expression of other receptors was unaltered. Since CXCR3 cells are enriched in cerebrospinal fluid (CSF), and are detected in lesion material in MS this may represent an important mode of action of interferon-beta in MS.

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Year:  2002        PMID： 11990865     DOI： 10.1191/1352458502ms781oa

Source DB:  PubMed          Journal:  Mult Scler        ISSN： 1352-4585            Impact factor:   6.312


  7 in total

1.  Type I Interferon Therapy Limits CNS Autoimmunity by Inhibiting CXCR3-Mediated Trafficking of Pathogenic Effector T Cells.

Authors:  Weiwei Wang; Wai Po Chong; Chunmei Li; Zilin Chen; Sihan Wu; Hongyan Zhou; Ying Wan; Wanjun Chen; Igal Gery; Yizhi Liu; Rachel R Caspi; Jun Chen
Journal:  Cell Rep       Date:  2019-07-09       Impact factor: 9.423

2.  CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy.

Authors:  Dennis M Lindell; Thomas E Lane; Nicholas W Lukacs
Journal:  Eur J Immunol       Date:  2008-08       Impact factor: 5.532

Review 3.  The CD8 T Cell-Epstein-Barr Virus-B Cell Trialogue: A Central Issue in Multiple Sclerosis Pathogenesis.

Authors:  Caterina Veroni; Francesca Aloisi
Journal:  Front Immunol       Date:  2021-07-07       Impact factor: 7.561

4.  A novel mechanism of soluble HLA-G mediated immune modulation: downregulation of T cell chemokine receptor expression and impairment of chemotaxis.

Authors:  Fabio Morandi; Elisa Ferretti; Paola Bocca; Ignazia Prigione; Lizzia Raffaghello; Vito Pistoia
Journal:  PLoS One       Date:  2010-07-23       Impact factor: 3.240

Review 5.  Chemokine-Driven Migration of Pro-Inflammatory CD4+ T Cells in CNS Autoimmune Disease.

Authors:  Aaron H S Heng; Caleb W Han; Caitlin Abbott; Shaun R McColl; Iain Comerford
Journal:  Front Immunol       Date:  2022-02-16       Impact factor: 7.561

6.  Interferon-β1b increases Th2 response in neuromyelitis optica.

Authors:  Hideto Nakajima; Takafumi Hosokawa; Yoshimitu Doi; Toshiyuki Ikemoto; Shimon Ishida; Fumiharu Kimura; Toshiaki Hanafusa
Journal:  Int J Mol Sci       Date:  2012-09-25       Impact factor: 5.923

7.  Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE.

Authors:  Sana Eltayeb; Anna-Lena Berg; Hans Lassmann; Erik Wallström; Maria Nilsson; Tomas Olsson; Anders Ericsson-Dahlstrand; Dan Sunnemark
Journal:  J Neuroinflammation       Date:  2007-05-07       Impact factor: 8.322
  7 in total

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