Literature DB >> 11985478

A trypanocidal phenazine derived from beta-lapachone.

Cleverson Neves-Pinto1, Valéria R S Malta, Maria do Carmo F R Pinto, Regina H A Santos, Solange L de Castro, Antônio Ventura Pinto.   

Abstract

An intensive effort has been directed toward finding alternative drugs for treatment of Chagas' disease, caused by Trypanosoma cruzi, and prophylaxis of blood in endemic areas. Our research comprises the synthesis and trypanocidal screening of derivatives from naphthoquinones. Herein a new phenazine, obtained from the reaction of beta-lapachone with aniline, has its structure established by physical data and X-ray analysis. It was 9 times more active against T. cruzi trypomastigotes than crystal violet.

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Year:  2002        PMID： 11985478     DOI： 10.1021/jm010377v

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  10 in total

1.  Epoxy-α-lapachone has in vitro and in vivo anti-leishmania (Leishmania) amazonensis effects and inhibits serine proteinase activity in this parasite.

Authors:  Franklin Souza-Silva; Saulo Cabral Bourguignon; Bernardo Acácio Santini Pereira; Luzia Monteiro de Castro Côrtes; Luiz Filipe Gonçalves de Oliveira; Andrea Henriques-Pons; Lea Cysne Finkelstein; Vitor Francisco Ferreira; Paula Fernandes Carneiro; Rosa Teixeira de Pinho; Ernesto Raul Caffarena; Carlos Roberto Alves
Journal:  Antimicrob Agents Chemother       Date:  2015-01-12       Impact factor: 5.191

2.  One-pot, sequential four-component synthesis of novel heterocyclic [3.3.3] propellane derivatives at room temperature.

Authors:  Maryam Beyrati; Alireza Hasaninejad
Journal:  RSC Adv       Date:  2018-04-17       Impact factor: 4.036

3.  An efficient and environmentally sustainable domino protocol for the synthesis of structurally diverse spiroannulated pyrimidophenazines using erbium doped TiO2 nanoparticles as a recyclable and reusable heterogeneous acid catalyst.

Authors:  Kanchan Verma; Yogesh Kumar Tailor; Sarita Khandelwal; Monu Agarwal; Esha Rushell; Yogita Kumari; Kamlendra Awasthi; Mahendra Kumar
Journal:  RSC Adv       Date:  2018-08-28       Impact factor: 4.036

4.  Oxyrane derivative of alpha-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms.

Authors:  Alessandra Jorqueira; Robson M Gouvêa; Vitor F Ferreira; Milton N da Silva; Maria C B V de Souza; Aline A Zuma; Danielle F B Cavalcanti; Humberto P Araújo; Dilvani O Santos; Saulo C Bourguignon
Journal:  Parasitol Res       Date:  2006-04-05       Impact factor: 2.383

5.  Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones.

Authors:  Solange L de Castro; Denise G J Batista; Marcos M Batista; Wanderson Batista; Anissa Daliry; Elen M de Souza; Rubem F S Menna-Barreto; Gabriel M Oliveira; Kelly Salomão; Cristiane F Silva; Patricia B Silva; Maria de Nazaré C Soeiro
Journal:  Mol Biol Int       Date:  2011-06-30

Review 6.  A review on lawsone-based benzo[a]phenazin-5-ol: synthetic approaches and reactions.

Authors:  Abolfazl Olyaei; Mahdieh Sadeghpour
Journal:  RSC Adv       Date:  2022-05-09       Impact factor: 4.036

7.  Two step, one-pot sequential synthesis of functionalized hybrid polyheterocyclic scaffolds via a solid state melt reaction (SSMR).

Authors:  Manickam Bakthadoss; Jayakumar Srinivasan; Mir Ashiq Hussain; Duddu S Sharada
Journal:  RSC Adv       Date:  2019-08-06       Impact factor: 4.036

8.  3,3-Dimethyl-cis-9a,13a-diphenyl-2,3,9a,11,12,13a-hexa-hydro-1H-benzo[h][1,4]dioxino[2',3':5,6][1,4]dioxino[2,3-f]chromene.

Authors:  Bauer O Bernardes; Aurelio B Buarque Ferreira; James L Wardell; Solange M S V Wardell; José C Netto-Ferreira; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-08-31

Review 9.  1,2-Naphthoquinone-4-sulfonic acid salts in organic synthesis.

Authors:  Ruan Carlos B Ribeiro; Patricia G Ferreira; Amanda de A Borges; Luana da S M Forezi; Fernando de Carvalho da Silva; Vitor F Ferreira
Journal:  Beilstein J Org Chem       Date:  2022-01-05       Impact factor: 2.883

Review 10.  The trypanocidal activity of naphthoquinones: a review.

Authors:  Antônio Ventura Pinto; Solange Lisboa de Castro
Journal:  Molecules       Date:  2009-11-10       Impact factor: 4.927
  10 in total

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