Literature DB >> 11980964

Correlation between the elastase activity index and invasiveness of clinical isolates of Aspergillus fumigatus.

Jose L Blanco1, Raquel Hontecillas, Emilio Bouza, Isabel Blanco, Teresa Pelaez, Patricia Muñoz, Jose Perez Molina, Marta E Garcia.   

Abstract

We calculated an elastase activity index (EAI) by dividing the diameter of the elastin lysis halo by the fungal growth diameter. After 10 days' incubation at 37 degrees C, all strains but one obtained from invasive aspergillosis showed an EAI > or = 1. Of the 18 strains obtained from colonized patients, only 4 (22.2%) had an EAI > or = 1, whereas neither of the strains isolated from patients with fungus ball reached this value. Overall, 44 out of the 142 strains obtained from the environment had an EAI > or = 1 (30.9%).

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Year:  2002        PMID： 11980964      PMCID： PMC130931          DOI： 10.1128/JCM.40.5.1811-1813.2002

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  12 in total

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Authors:  B C Starcher
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Authors:  A Kumar; L V Reddy; A Sochanik; V P Kurup
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Journal:  Infect Immun       Date:  1984-01       Impact factor: 3.441

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Journal:  Infect Immun       Date:  1991-01       Impact factor: 3.441

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Authors:  P Sutton; N R Newcombe; P Waring; A Müllbacher
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10.  Evidence for possible involvement of an elastolytic serine protease in aspergillosis.

Authors:  P E Kolattukudy; J D Lee; L M Rogers; P Zimmerman; S Ceselski; B Fox; B Stein; E A Copelan
Journal:  Infect Immun       Date:  1993-06       Impact factor: 3.441
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Review 5.  Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis.

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8.  Elastase Activity in Aspergillus fumigatus Can Arise by Random, Spontaneous Mutations.

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