Literature DB >> 11976384

Layer I ectopias and increased excitability in murine neocortex.

Lisa A Gabel1, Joseph J LoTurco.   

Abstract

Cortical dysplasias are associated with both epilepsy and cognitive impairments in humans. Similarly, several animal models of cortical dysplasia show that dysplasia causes increased seizure susceptibility and behavioral deficits in vivo and increased levels of excitability in vitro. As most current animal models involve either global disruptions in cortical architecture or the induction of lesions, it is not yet clear whether small spontaneous neocortical malformations are also associated with increased excitability or seizure susceptibility. Small groups of displaced neurons in layer I of the neocortex, ectopias, have been identified in patients with cognitive impairments, and similar malformations occur sporadically in some inbred lines of mice where they are associated with behavioral and sensory-processing deficits. In a previous study, we characterized the physiology of cells within neocortical ectopias, in one of the inbred lines (NXSM-D/Ei) and showed that the presence of multiple ectopias is associated with the generation of spontaneous epileptiform activity in slices. In this study, we use extracellular recordings from brain slices to show that even single-layer I ectopias are associated with higher excitability. Specifically, slices that contain single ectopias display epileptiform activity at significantly lower concentrations of the GABA(A) receptor antagonist bicuculline than do slices without ectopias (either from opposite hemispheres or animals without ectopias). Moreover, because removal of ectopias from slices does not restore normal excitability, enhanced excitability is not generated within the ectopia. Finally, we show that in vivo, mice with ectopias are more sensitive to the convulsant pentylenetetrazole than are mice without ectopias. Together these results suggest that alterations in cortical hemispheres containing focal layer I malformations increase cortical excitability and that even moderately small spontaneous cortical dysplasias are associated with increased excitability in vitro and in vivo.

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Year:  2002        PMID: 11976384     DOI: 10.1152/jn.2002.87.5.2471

Source DB:  PubMed          Journal:  J Neurophysiol        ISSN: 0022-3077            Impact factor:   2.714


  8 in total

1.  Layer I neocortical ectopia: cellular organization and local cortical circuitry.

Authors:  Lisa Ann Gabel
Journal:  Brain Res       Date:  2011-01-20       Impact factor: 3.252

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3.  Differential seizure response in two models of cortical heterotopia.

Authors:  Lisa A Gabel; Monica Manglani; Natalia Ibanez; Jessica Roberts; Raddy L Ramos; Glenn D Rosen
Journal:  Brain Res       Date:  2012-11-29       Impact factor: 3.252

4.  Detection of silent gaps in white noise following cortical deactivation in rats.

Authors:  Steven W Threlkeld; Stephanie C Penley; Glenn D Rosen; Roslyn Holly Fitch
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5.  Postnatal analysis of the effect of embryonic knockdown and overexpression of candidate dyslexia susceptibility gene homolog Dcdc2 in the rat.

Authors:  T J Burbridge; Y Wang; A J Volz; V J Peschansky; L Lisann; A M Galaburda; J J Lo Turco; G D Rosen
Journal:  Neuroscience       Date:  2008-01-19       Impact factor: 3.590

6.  Cytoarchitecture and transcriptional profiles of neocortical malformations in inbred mice.

Authors:  Raddy L Ramos; Phoebe T Smith; Christopher DeCola; Danny Tam; Oscar Corzo; Joshua C Brumberg
Journal:  Cereb Cortex       Date:  2008-02-27       Impact factor: 5.357

7.  Intravital Imaging of Neocortical Heterotopia Reveals Aberrant Axonal Pathfinding and Myelination around Ectopic Neurons.

Authors:  Alice M Li; Robert A Hill; Jaime Grutzendler
Journal:  Cereb Cortex       Date:  2021-07-29       Impact factor: 4.861

8.  Enhanced Glutamatergic Currents at Birth in Shank3 KO Mice.

Authors:  Morgane Chiesa; Romain Nardou; Natalia Lozovaya; Sanaz Eftekhari; Roman Tyzio; Damien Guimond; Diana C Ferrari; Yehezkel Ben-Ari
Journal:  Neural Plast       Date:  2019-07-03       Impact factor: 3.599

  8 in total

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