Literature DB >> 11973326

The chromosome 1;11 translocation provides the best evidence supporting genetic etiology for schizophrenia and bipolar affective disorders.

Amar J S Klar1.   

Abstract

Genetics is assumed to cause susceptibility to psychosis, but no major locus has been identified. These disorders cosegregate with a chromosome 1;11 translocation in a Scottish pedigree where 50% of the carriers are diseased. A genetic model originally proposed to explain the basis of these illnesses predicts such an outcome.

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Year:  2002        PMID： 11973326      PMCID： PMC1462039     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  10 in total

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3.  Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.

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4.  Association within a family of a balanced autosomal translocation with major mental illness.

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Review 8.  A model for specification of the left-right axis in vertebrates.

Authors:  A J Klar
Journal:  Trends Genet       Date:  1994-11       Impact factor: 11.639

9.  Disruption of two novel genes by a translocation co-segregating with schizophrenia.

Authors:  J K Millar; J C Wilson-Annan; S Anderson; S Christie; M S Taylor; C A Semple; R S Devon; D M St Clair; W J Muir; D H Blackwood; D J Porteous
Journal:  Hum Mol Genet       Date:  2000-05-22       Impact factor: 6.150

10.  Schizophrenia, brain asymmetry development, and twinning: cellular relationship with etiological and possibly prognostic implications.

Authors:  C E Boklage
Journal:  Biol Psychiatry       Date:  1977-02       Impact factor: 13.382
  10 in total
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Authors:  Amar J S Klar
Journal:  Genetics       Date:  2005-06-08       Impact factor: 4.562

3.  A genetic mechanism implicates chromosome 11 in schizophrenia and bipolar diseases.

Authors:  Amar J S Klar
Journal:  Genetics       Date:  2004-08       Impact factor: 4.562

4.  A hypothesis for how chromosome 11 translocations cause psychiatric disorders.

Authors:  Gurjeet Singh; Amar J S Klar
Journal:  Genetics       Date:  2007-08-24       Impact factor: 4.562

5.  Support for the selective chromatid segregation hypothesis advanced for the mechanism of left-right body axis development in mice.

Authors:  Amar J S Klar
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Review 6.  Split hand/foot malformation genetics supports the chromosome 7 copy segregation mechanism for human limb development.

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Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-12-19       Impact factor: 6.237

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  7 in total

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