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Literature DB >> 11973323

Homozygosity and linkage disequilibrium.

Abstract

We illustrate how homozygosity of haplotypes can be used to measure the level of disequilibrium between two or more markers. An excess of either homozygosity or heterozygosity signals a departure from the gametic phase equilibrium: We describe the specific form of dependence that is associated with high (low) homozygosity and derive various linkage disequilibrium measures. They feature a clear biological interpretation, can be used to construct tests, and are standardized to allow comparison across loci and populations. They are particularly advantageous to measure linkage disequilibrium between highly polymorphic markers.

Mesh：

Substances：
Genetic Markers

Year: 2002 PMID： 11973323 PMCID： PMC1462072

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

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5. Biases and reconciliation in estimates of linkage disequilibrium in the human genome.

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7. Contribution of an additive locus to genetic variance when inheritance is multi-factorial with implications on interpretation of GWAS.

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