BACKGROUND: Combined liver resection and local ablation may offer the only chance of cure to patients with liver metastases who are presently deemed unresectable because of a single awkwardly placed metastasis. By definition, such a metastasis is often close to a major vein. An ablative technique is needed that is both predictable and safe in such a circumstance. METHODS: Electrolytic liver lesions were created in 21 pigs using platinum electrodes, connected to a direct current generator. Both electrolytic 'dose' and electrode separation were varied to produce different sized lesions. The 'dose' was correlated with the volume of necrosis and any vascular damage was determined histologically. RESULTS: There was a significant (P < 0.001) correlation between the electrolytic 'dose' and the volume of liver necrosis. For a given 'dose' the volume of necrosis was less when the electrodes were together, rather than separated. Liver enzymes were only transiently deranged. There were no significant vascular injuries. CONCLUSION: Predictable and reproducible necrosis is produced by electrolysis in the pig liver. The treatment appears to cause little or no damage to immediately adjacent liver or major vascular structures and, when combined with resection, may offer the chance of a cure to many patients who are currently unresectable.
BACKGROUND: Combined liver resection and local ablation may offer the only chance of cure to patients with liver metastases who are presently deemed unresectable because of a single awkwardly placed metastasis. By definition, such a metastasis is often close to a major vein. An ablative technique is needed that is both predictable and safe in such a circumstance. METHODS: Electrolytic liver lesions were created in 21 pigs using platinum electrodes, connected to a direct current generator. Both electrolytic 'dose' and electrode separation were varied to produce different sized lesions. The 'dose' was correlated with the volume of necrosis and any vascular damage was determined histologically. RESULTS: There was a significant (P < 0.001) correlation between the electrolytic 'dose' and the volume of liver necrosis. For a given 'dose' the volume of necrosis was less when the electrodes were together, rather than separated. Liver enzymes were only transiently deranged. There were no significant vascular injuries. CONCLUSION: Predictable and reproducible necrosis is produced by electrolysis in the pig liver. The treatment appears to cause little or no damage to immediately adjacent liver or major vascular structures and, when combined with resection, may offer the chance of a cure to many patients who are currently unresectable.
Authors: Gianpiero Gravante; Seok Ling Ong; Kevin West; Angus McGregor; Guy J Maddern; Matthew S Metcalfe; David M Lloyd; Ashley R Dennison Journal: Pathol Oncol Res Date: 2012-06-17 Impact factor: 3.201
Authors: Héctor Manuel Camué Ciria; Maraelys Morales González; Lisset Ortíz Zamora; Luis Enrique Bergues Cabrales; Gustavo Victoriano Sierra González; Luciana Oliveira de Oliveira; Rodrigo Zanella; Antonio Carlos Buzaid; Orlando Parise; Luciana Macedo Brito; Cesar Augusto Antunes Teixeira; Marina das Neves Gomes; Gleyce Moreno; Venicio Feo da Veiga; Marcos Telló; Carla Holandino Journal: Chin J Cancer Res Date: 2013-04 Impact factor: 5.087
Authors: H C Ciria; M S Quevedo; L B Cabrales; R P Bruzón; M F Salas; O G Pena; T R González; D S López; J M Flores Journal: BMC Cancer Date: 2004-11-26 Impact factor: 4.430
Authors: Nicholas R Perkons; Elliot J Stein; Chike Nwaezeapu; Joseph C Wildenberg; Kamiel Saleh; Roni Itkin-Ofer; Daniel Ackerman; Michael C Soulen; Stephen J Hunt; Gregory J Nadolski; Terence P Gade Journal: Commun Biol Date: 2018-05-17