Literature DB >> 11971828

An evidence based flowchart to guide the management of acute salicylate (aspirin) overdose.

P I Dargan1, C I Wallace, A L Jones.   

Abstract

OBJECTIVE: To develop a flowchart to be used as a tool to guide clinicians step by step through the management of salicylate poisoning.
METHODS: A comprehensive literature search was carried out.
RESULTS: The evidence base was used to develop a management flowchart that guides the clinician through the three main steps in caring for the patient with salicylate poisoning: preventing further absorption, assessing the severity of poisoning and, where appropriate, increasing elimination.
CONCLUSIONS: Salicylate poisoning can result in severe morbidity and mortality and this flowchart provides an evidence based guideline that will guide clinicians through the management of patients presenting to the emergency department with salicylate poisoning.

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Year:  2002        PMID: 11971828      PMCID: PMC1725844          DOI: 10.1136/emj.19.3.206

Source DB:  PubMed          Journal:  Emerg Med J        ISSN: 1472-0205            Impact factor:   2.740


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Journal:  Hum Toxicol       Date:  1983-04

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Journal:  Pediatrics       Date:  1960-11       Impact factor: 7.124

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  17 in total

Review 1.  Acute poisoning: understanding 90% of cases in a nutshell.

Authors:  S L Greene; P I Dargan; A L Jones
Journal:  Postgrad Med J       Date:  2005-04       Impact factor: 2.401

2.  An adult can still die of salicylate poisoning in France in 2008.

Authors:  Arnaud Galbois; Hafid Ait-Oufella; Jean-Luc Baudel; Eric Maury; Georges Offenstadt
Journal:  Intensive Care Med       Date:  2009-06-18       Impact factor: 17.440

3.  Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.

Authors:  Rupesh Raina; Manpreet K Grewal; Martha Blackford; Jordan M Symons; Michael J G Somers; Christoph Licht; Rajit K Basu; Sidharth Kumar Sethi; Deepa Chand; Gaurav Kapur; Mignon McCulloch; Arvind Bagga; Vinod Krishnappa; Hui-Kim Yap; Marcelo de Sousa Tavares; Timothy E Bunchman; Michelle Bestic; Bradley A Warady; Maria Díaz-González de Ferris
Journal:  Pediatr Nephrol       Date:  2019-08-24       Impact factor: 3.714

Review 4.  Antimicrobial Effects of Antipyretics.

Authors:  Petra Zimmermann; Nigel Curtis
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

5.  Treatment of lethal acetylsalicylic acid poisoning without hemodialysis.

Authors:  Masahito Ueno; Jun Oda; Hiroshi Soeda; Hirotaka Uesugi; Keiko Ueno; Yo Fujise; Tetsuo Yukioka
Journal:  Acute Med Surg       Date:  2014-08-08

6.  Measuring plasma salicylate concentrations in all patients with drug overdose or altered consciousness: is it necessary?

Authors:  D M Wood; P I Dargan; A L Jones
Journal:  Emerg Med J       Date:  2005-06       Impact factor: 2.740

7.  Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545.

Authors:  Mariya S Liyasova; Lawrence M Schopfer; Oksana Lockridge
Journal:  Biochem Pharmacol       Date:  2009-10-27       Impact factor: 5.858

Review 8.  Aspirin resistance and other aspirin-related concerns.

Authors:  Gaoyu Cai; Weijun Zhou; Ya Lu; Peili Chen; Zhongjiao Lu; Yi Fu
Journal:  Neurol Sci       Date:  2015-11-14       Impact factor: 3.307

Review 9.  Pharmacokinetic considerations in clinical toxicology: clinical applications.

Authors:  Darren M Roberts; Nick A Buckley
Journal:  Clin Pharmacokinet       Date:  2007       Impact factor: 6.447

10.  Accidental overdose in the deep shade of night: a warning on the assumed safety of 'natural substances'.

Authors:  Andrew Chadwick; Abigail Ash; James Day; Mark Borthwick
Journal:  BMJ Case Rep       Date:  2015-11-05
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