Rupesh Raina1,2, Manpreet K Grewal3, Martha Blackford4, Jordan M Symons5, Michael J G Somers6, Christoph Licht7, Rajit K Basu8, Sidharth Kumar Sethi9, Deepa Chand10, Gaurav Kapur11, Mignon McCulloch12, Arvind Bagga13, Vinod Krishnappa3, Hui-Kim Yap14, Marcelo de Sousa Tavares15, Timothy E Bunchman16, Michelle Bestic4, Bradley A Warady17, Maria Díaz-González de Ferris18. 1. Department of Nephrology, Akron Children's Hospital, Akron, OH, USA. RRaina@akronchildrens.org. 2. Akron Nephrology Associates/Cleveland Clinic Akron General, 224 W. Exchange St., Akron, OH, 44302, USA. RRaina@akronchildrens.org. 3. Akron Nephrology Associates/Cleveland Clinic Akron General, 224 W. Exchange St., Akron, OH, 44302, USA. 4. Division of Clinical Pharmacology & Toxicology, Akron Children's Hospital, Akron, OH, USA. 5. Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA. 6. Division of Nephrology, Boston Children's Hospital, Boston, MA, USA. 7. Division of Nephrology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada. 8. Department of Pediatric Critical Care Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USA. 9. Pediatric Nephrology & Pediatric Kidney Transplantation, Kidney and Urology Institute, Medanta, The Medicity Hospital, Gurgaon, India. 10. Division of Pediatric Nephrology, Washington University School of Medicine, St. Louis, MO, USA. 11. Department of Pediatric Nephrology, Children's Hospital of Michigan, Wayne State University, Detroit, MI, USA. 12. Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. 13. Division of Paediatric Nephrology, All India Institute of Medical Sciences, New Delhi, India. 14. Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 15. Department of Paediatrics, Medical School, Universidade Nove de Julho, São Paulo, Brazil. 16. Pediatric Nephrology & Transplantation, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, VA, USA. 17. Division of Pediatric Nephrology, Children's Mercy Kansas City, Kansas City, MO, USA. 18. Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Abstract
BACKGROUND: Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). METHODS: We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement Therapy) workgroup assessed titles, abstracts, and full-text articles for extraction of data. The data from the literature search was shared with the PCRRT workgroup and two expert toxicologists, and expert panel recommendations were developed. RESULTS AND CONCLUSIONS: We have presented the recommendations concerning the use of RRTs for treatment of intoxications with toxic alcohols, lithium, vancomycin, theophylline, barbiturates, metformin, carbamazepine, methotrexate, phenytoin, acetaminophen, salicylates, valproic acid, and aminoglycosides.
BACKGROUND: Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). METHODS: We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement Therapy) workgroup assessed titles, abstracts, and full-text articles for extraction of data. The data from the literature search was shared with the PCRRT workgroup and two expert toxicologists, and expert panel recommendations were developed. RESULTS AND CONCLUSIONS: We have presented the recommendations concerning the use of RRTs for treatment of intoxications with toxic alcohols, lithium, vancomycin, theophylline, barbiturates, metformin, carbamazepine, methotrexate, phenytoin, acetaminophen, salicylates, valproic acid, and aminoglycosides.