Literature DB >> 11967804

Insights derived from ACE knockout mice.

J Cole, D Ertoy, K E Bernstein.   

Abstract

The evaluation of ACE knockout mice has illustrated the tremendous physiologic importance of the RAAS. We have discussed how interruption of this system influences blood pressure, renal function, renal development, serum and urine electrolyte composition, haematocrit and male reproductive capacity. This body of data underlines the modelling of the RAAS as a type of biological machine that is positioned to respond to environmental insult and to maintain a homeostasis of blood pressure, blood volume and electrolyte composition. These data also emphasise Harry Goldblatt's seminal observation that the kidney and the RAAS are intimately linked in the regulation of normal blood pressure.

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Year:  2000        PMID： 11967804     DOI： 10.3317/jraas.2000.016

Source DB:  PubMed          Journal:  J Renin Angiotensin Aldosterone Syst        ISSN： 1470-3203            Impact factor:   1.636


  9 in total

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Review 3.  Brain renin-angiotensin system in the nexus of hypertension and aging.

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Authors:  Tu H Mai; Jing Wu; André Diedrich; Emily M Garland; David Robertson
Journal:  J Am Soc Hypertens       Date:  2014-03-13

Review 5.  Neuro-hormonal effects of physical activity in the elderly.

Authors:  Grazia D Femminella; Claudio de Lucia; Paola Iacotucci; Roberto Formisano; Laura Petraglia; Elena Allocca; Enza Ratto; Loreta D'Amico; Carlo Rengo; Gennaro Pagano; Domenico Bonaduce; Giuseppe Rengo; Nicola Ferrara
Journal:  Front Physiol       Date:  2013-12-20       Impact factor: 4.566

Review 6.  ACE and ACE2: insights from Drosophila and implications for COVID-19.

Authors:  Paul Herrera; Ruben J Cauchi
Journal:  Heliyon       Date:  2021-12-07

Review 7.  Exploring the Impact of ACE Inhibition in Immunity and Disease.

Authors:  Delia Oosthuizen; Edward D Sturrock
Journal:  J Renin Angiotensin Aldosterone Syst       Date:  2022-08-04       Impact factor: 4.109

8.  Multi-species comparative analysis of the equine ACE gene identifies a highly conserved potential transcription factor binding site in intron 16.

Authors:  Natasha A Hamilton; Imke Tammen; Herman W Raadsma
Journal:  PLoS One       Date:  2013-02-08       Impact factor: 3.240

9.  Tissue-specific expression of transgenic secreted ACE in vasculature can restore normal kidney functions, but not blood pressure, of Ace-/- mice.

Authors:  Saurabh Chattopadhyay; Sean P Kessler; Juliana Almada Colucci; Michifumi Yamashita; Preenie deS Senanayake; Ganes C Sen
Journal:  PLoS One       Date:  2014-01-27       Impact factor: 3.240
  9 in total

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