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Literature DB >> 11965366

Synthesis of aminoglycoside-DNA conjugates.

Abstract

Development of aminoglycoside-nucleic acid conjugates is presented. Synthesis of a DNA dimer covalently linked to kanamycin and neomycin isothiocyanates has been carried out. The development of such conjugates will help couple the sequence specificity of nucleic acids to the electrostatic/shape complementarity of aminoglycoside antibiotics in binding nucleic acid targets.

Entities: Chemical

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Year: 2002 PMID： 11965366 DOI： 10.1016/s0960-894x(02)00157-9

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

10 in total

1. Click dimers to target HIV TAR RNA conformation.

Authors: Sunil Kumar; Patrick Kellish; W Edward Robinson; Deyun Wang; Daniel H Appella; Dev P Arya
Journal: Biochemistry Date: 2012-03-09 Impact factor: 3.162

Review 2. New approaches toward recognition of nucleic acid triple helices.

Authors: Dev P Arya
Journal: Acc Chem Res Date: 2010-11-12 Impact factor: 22.384

3. Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates.

Authors: Nihar Ranjan; Sunil Kumar; Derrick Watkins; Deyun Wang; Daniel H Appella; Dev P Arya
Journal: Bioorg Med Chem Lett Date: 2013-08-14 Impact factor: 2.823

4. Utilization of chromic polydiacetylene assemblies as a platform to probe specific binding between drug and RNA.

Authors: Anothai Kamphan; Changjun Gong; Krishnagopal Maiti; Souvik Sur; Rakchart Traiphol; Dev P Arya
Journal: RSC Adv Date: 2017-08-24 Impact factor: 3.361

Review 5. Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

Authors: Nishad Thamban Chandrika; Sylvie Garneau-Tsodikova
Journal: Chem Soc Rev Date: 2018-02-19 Impact factor: 54.564

Synthesis of aminoglycoside-DNA conjugates.

1. Click dimers to target HIV TAR RNA conformation.

Review 2. New approaches toward recognition of nucleic acid triple helices.

3. Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates.

4. Utilization of chromic polydiacetylene assemblies as a platform to probe specific binding between drug and RNA.

Review 5. Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

6. Thermodynamics of nucleic acid "shape readout" by an aminosugar.

7. Influence of linker length in shape recognition of B* DNA by dimeric aminoglycosides.

8. Aminoglycoside binding to Oxytricha nova telomeric DNA.

9. Neomycin-neomycin dimer: an all-carbohydrate scaffold with high affinity for AT-rich DNA duplexes.

10. Probing the recognition surface of a DNA triplex: binding studies with intercalator-neomycin conjugates.