Literature DB >> 11960669

3-O-substituted benzyl pyridazinone derivatives as COX inhibitors.

Vamsee Krishna Chintakunta1, Venkateswarlu Akella, Manohar Sharma Vedula, Prem Kumar Mamnoor, Parimal Mishra, Seshagiri Rao Casturi, Akhila Vangoori, Ramanujam Rajagopalan.   

Abstract

New 3-O-substituted benzyl pyridazinone compounds have been synthesised and evaluated for their cyclooxygenase inhibitory activity and COX-2 selectivity. Among the compounds synthesised, three compounds (11b-11d) have shown in vitro COX-2 selectivity. These compounds have been evaluated for their in vivo potential using carrageenan-induced rat paw edema assay. One compound (11b) showed 32% anti-inflammatory activity at 30 mgkg(-1) dose.

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Year:  2002        PMID： 11960669     DOI： 10.1016/s0223-5234(02)01336-3

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  3 in total

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Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

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Authors:  Hormi Mecadon; Bekington Myrboh
Journal:  ISRN Org Chem       Date:  2011-04-12

3.  Approaches towards the synthesis of a novel class of 2-amino-5-arylazonicotinate, pyridazinone and pyrido[2,3-d]pyrimidine derivatives as potent antimicrobial agents.

Authors:  Hamada Mohamed Ibrahim; Haider Behbehani; Mohamed H Elnagdi
Journal:  Chem Cent J       Date:  2013-07-17       Impact factor: 4.215
  3 in total

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