Literature DB >> 11960309

Association between IL-4 genotype and IL-4 production in the Japanese population.

H Nakashima1, K Miyake, Y Inoue, S Shimizu, M Akahoshi, Y Tanaka, T Otsuka, M Harada.   

Abstract

We have identified that there are only two IL-4 gene haplotypes (I and II) in the Japanese population. There are significant differences among three genotypes (I/I, I/II and II/II) in the IL-4 producing proportion of peripheral Th cells using intracellular cytokine detection assay. These results make it likely that IL-4 genotype could influence the type of immune response.

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Year:  2002        PMID： 11960309     DOI： 10.1038/sj.gene.6363830

Source DB:  PubMed          Journal:  Genes Immun        ISSN： 1466-4879            Impact factor:   2.676


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