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Literature DB >> 11959595

30S ribosomal subunit assembly is a target for inhibition by aminoglycosides in Escherichia coli.

Abstract

The aminoglycosides paromomycin and neomycin were examined in Escherichia coli cells for an inhibitory effect on 30S ribosomal subunit assembly. Both compounds inhibited the growth rate, viable cell number, and protein synthesis rate with similar 50% inhibitory concentrations. Each drug also showed a concentration-dependent inhibition of 30S subunit formation. The inhibitory effect on 30S particle formation was approximately equivalent to the inhibitory effect on translation for these antibiotics.

Entities: Chemical Species

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Year: 2002 PMID： 11959595 PMCID： PMC127183 DOI： 10.1128/AAC.46.5.1546-1549.2002

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

18 in total

Review 1. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance.

Authors: L P Kotra; J Haddad; S Mobashery
Journal: Antimicrob Agents Chemother Date: 2000-12 Impact factor: 5.191

2. Recognition of cognate transfer RNA by the 30S ribosomal subunit.

Authors: J M Ogle; D E Brodersen; W M Clemons ; M J Tarry; A P Carter; V Ramakrishnan
Journal: Science Date: 2001-05-04 Impact factor: 47.728

Review 3. Aminoglycosides: activity and resistance.

Authors: M P Mingeot-Leclercq; Y Glupczynski; P M Tulkens
Journal: Antimicrob Agents Chemother Date: 1999-04 Impact factor: 5.191

Review 4. Bacterial ribosomal subunit synthesis: a novel antibiotic target.

Authors: W S Champney
Journal: Curr Drug Targets Infect Disord Date: 2001-05

5. Structure-activity relationships for six ketolide antibiotics.

Authors: W S Champney; C L Tober
Journal: Curr Microbiol Date: 2001-03 Impact factor: 2.188

6. Effect of mutations in the A site of 16 S rRNA on aminoglycoside antibiotic-ribosome interaction.

Authors: M I Recht; S Douthwaite; K D Dahlquist; J D Puglisi
Journal: J Mol Biol Date: 1999-02-12 Impact factor: 5.469

Review 7. Modulation of RNA function by aminoglycoside antibiotics.

Authors: R Schroeder; C Waldsich; H Wank
Journal: EMBO J Date: 2000-01-04 Impact factor: 11.598

8. Localized mutagenesis for the isolation of temperature-sensitive mutants of Escherichia coli affected in protein synthesis.

Authors: W S Champney
Journal: Genetics Date: 1979-02 Impact factor: 4.562

9. Variation in the proportion of 50S and 30S ribosomal subunits at different growth rates.

Authors: G A Michaels
Journal: J Bacteriol Date: 1971-07 Impact factor: 3.490

10. A comparison of the inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by nine different macrolide antibiotics.

Authors: W S Champney; C L Tober; R Burdine
Journal: Curr Microbiol Date: 1998-12 Impact factor: 2.188

27 in total

10. Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics.

Authors: Miloje Savic; Josip Lovric; Tatjana Ilic Tomic; Branka Vasiljevic; Graeme L Conn
Journal: Nucleic Acids Res Date: 2009-07-09 Impact factor: 16.971

30S ribosomal subunit assembly is a target for inhibition by aminoglycosides in Escherichia coli.

Review 1. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance.

2. Recognition of cognate transfer RNA by the 30S ribosomal subunit.

Review 3. Aminoglycosides: activity and resistance.

Review 4. Bacterial ribosomal subunit synthesis: a novel antibiotic target.

5. Structure-activity relationships for six ketolide antibiotics.

6. Effect of mutations in the A site of 16 S rRNA on aminoglycoside antibiotic-ribosome interaction.

Review 7. Modulation of RNA function by aminoglycoside antibiotics.

8. Localized mutagenesis for the isolation of temperature-sensitive mutants of Escherichia coli affected in protein synthesis.

9. Variation in the proportion of 50S and 30S ribosomal subunits at different growth rates.

10. A comparison of the inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by nine different macrolide antibiotics.

1. Inhibition of protein synthesis by aminoglycoside-arginine conjugates.

2. Group I intron renders differential susceptibility of Candida albicans to Bleomycin.

Review 3. Inhibition of bacterial ribosome assembly: a suitable drug target?

4. Hygromycin B inhibition of protein synthesis and ribosome biogenesis in Escherichia coli.

5. Mutational activation of the AmgRS two-component system in aminoglycoside-resistant Pseudomonas aeruginosa.

6. An unexpected type of ribosomes induced by kasugamycin: a look into ancestral times of protein synthesis?

7. Membrane voltage dysregulation driven by metabolic dysfunction underlies bactericidal activity of aminoglycosides.

Review 8. Versatility of aminoglycosides and prospects for their future.

9. Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid.

10. Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics.