| Literature DB >> 11958977 |
Timothy A Blizzard1, Ronald M Kim, Jerry D Morgan, Jiang Chang, Joyce Kohler, Ruth Kilburn, Kevin Chapman, Milton L Hammond.
Abstract
A series of G6-amino derivatives of a lipophilic vancomycin analogue was prepared. Antibacterial activity of the analogues was inversely proportional to the degree of substitution of the G6-nitrogen. The fully substituted (quaternary) analogues were essentially inactive against vanA phenotype VREF strains but retained substantial activity against other bacteria, a profile reminiscent of teicoplanin.Entities:
Mesh：
Substances：
Year: 2002 PMID： 11958977 DOI： 10.1016/s0960-894x(02)00049-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823