Literature DB >> 119583

Comparative metabolism and excretion of adriamycin in man, monkey, and rat.

P M Wilkinson, M Israel, W J Pegg, E Frei.   

Abstract

Adriamycin and its fluorescent metabolites in bile (man, monkey, and rat) and urine (man and monkey) were determined by means of a simple, rapid, and highly reproducible high-performance liquid chromatographic procedure. Species differences in metabolism and biliary excretion were observed with respect to aldoketo reductase and conjugase activities.

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Year:  1979        PMID： 119583     DOI： 10.1007/bf00254084

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  19 in total

1.  Bilary disposition of adriamycin.

Authors:  C E Riggs; R S Benjamin; A A Serpick; N R Bachur
Journal:  Clin Pharmacol Ther       Date:  1977-08       Impact factor: 6.875

2.  Adriamycin metabolism in man. Evidence from urinary metabolites.

Authors:  S Takanashi; N R Bachur
Journal:  Drug Metab Dispos       Date:  1976 Jan-Feb       Impact factor: 3.922

3.  Distribution of daunomycin and adriamycin in mice. A comparative study.

Authors:  R Rosso; M Esposito; R Sala; L Santi
Journal:  Biomedicine       Date:  1973-07-20

4.  Adriamycin and daunorubicin disposition in the rabbit.

Authors:  N R Bachur; R C Hildebrand; R S Jaenke
Journal:  J Pharmacol Exp Ther       Date:  1974-11       Impact factor: 4.030

5.  Analysis of the pharmacokinetic characteristics, pharmacological and chemotherapeutic activity of 14-Hydroxy-daunomycin (Adriamycin), a new drug endowed with an antitumour activity.

Authors:  E Arena; N D'Alessandro; L Dusonchet; N Gebbia; F Gerbasi; M Palazzoadriano; A Raineri; L Rausa; E Tubaro
Journal:  Arzneimittelforschung       Date:  1971-08

6.  Pharmacokinetics and metabolism of adriamycin in man.

Authors:  R S Benjamin; C E Riggs; N R Bachur
Journal:  Clin Pharmacol Ther       Date:  1973 Jul-Aug       Impact factor: 6.875

7.  Daunorubicin biliary excretion and metabolism in the rat.

Authors:  J C Cradock; M J Egorin; N R Bachur
Journal:  Arch Int Pharmacodyn Ther       Date:  1973-03

8.  Daunorubicin metabolism in acute nonlymphocytic leukemia.

Authors:  D H Huffman; R S Benjamin; N R Bachur
Journal:  Clin Pharmacol Ther       Date:  1972 Nov-Dec       Impact factor: 6.875

9.  Distribution and metabolism of daunomycin, adriamycin, and N-acetyldaunomycin in the Syrian golden hamster.

Authors:  R M Mhatre; E H Herman; V S Waravdekar; I P Lee
Journal:  Biochem Med       Date:  1972-10

10.  Hepatobiliary metabolism and excretion of adriamycin and N-trifluoroacetyladriamycin-14-valerate in the rat.

Authors:  M Israel; P M Wilkinson; W J Pegg; E Frei
Journal:  Cancer Res       Date:  1978-02       Impact factor: 12.701
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  12 in total

1.  Development and identification of a multicompartment model for the distribution of adriamycin in the rat.

Authors:  P Sonneveld; J A Mulder
Journal:  J Pharmacokinet Biopharm       Date:  1981-10

2.  Doxorubicin and doxorubicinol plasma concentrations and excretion in parotid saliva.

Authors:  F Bressolle; J M Jacquet; M Galtier; J Jourdan; D Donadio; J F Rossi
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

Review 3.  Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties.

Authors:  J Bouma; J H Beijnen; A Bult; W J Underberg
Journal:  Pharm Weekbl Sci       Date:  1986-04-25

4.  Metabolism of epidoxorubicin in animals: absence of glucuronidation.

Authors:  P A Maessen; K B Mross; H M Pinedo; W J van der Vijgh
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

5.  Disposition of 14C-labelled 4'-epidoxorubicin and doxorubicin in the rat. A comparative study.

Authors:  F Arcamone; M Lazzati; G P Vicario; G Zini
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

6.  Doxorubicin and 5-fluorouracil plasma concentrations and detectability in parotid saliva.

Authors:  L A Celio; G J DiGregorio; E Ruch; J Pace; A J Piraino
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

7.  Hepatic extraction, metabolism and biliary excretion of doxorubicin in the isolated perfused rat liver.

Authors:  F Ballet; P Vrignaud; J Robert; C Rey; R Poupon
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

8.  Effect of cyclophosphamide pretreatment on the short-term disposition and biliary excretion of adriamycin metabolites in rat.

Authors:  N Hartman; P J Basseches; G Powis
Journal:  Cancer Chemother Pharmacol       Date:  1982-12       Impact factor: 3.333

Review 9.  Clinical pharmacokinetics of commonly used anticancer drugs.

Authors:  F M Balis; J S Holcenberg; W A Bleyer
Journal:  Clin Pharmacokinet       Date:  1983 May-Jun       Impact factor: 6.447

10.  Hepatic metabolism of doxorubicin in mice and rats.

Authors:  P Vrignaud; D Londos-Gagliardi; J Robert
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1986 Apr-Jun       Impact factor: 2.441
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