BACKGROUND: The purpose of the study was to investigate and identify abnormal brain activity, as revealed by event-related potentials (ERPs) concurring with deficient inhibitory control in children with attention-deficit/hyperactivity disorder (ADHD). METHODS: Performance and ERPs from 16 children with ADHD and 16 control subjects were compared in the stop-signal paradigm. RESULTS: The ADHD children showed a lower inhibition percentage and their (estimated) response time to the stop signal was disproportionally longer compared to the slowing of reaction times to primary-task stimuli. In normal control subjects, fronto-central positivity (100-400 msec) after the onset of the stop-signal was larger in case of successful inhibition, relative to failed inhibition; this was less so in ADHD children. A late positive wave (500-700 msec), maximal at Oz on failed inhibition trials, and possibly related to error-detection, was smaller in ADHD children. CONCLUSIONS: These results point to abnormalities in brain processes involved in motor inhibition and error-detection in ADHD children.
BACKGROUND: The purpose of the study was to investigate and identify abnormal brain activity, as revealed by event-related potentials (ERPs) concurring with deficient inhibitory control in children with attention-deficit/hyperactivity disorder (ADHD). METHODS: Performance and ERPs from 16 children with ADHD and 16 control subjects were compared in the stop-signal paradigm. RESULTS: The ADHDchildren showed a lower inhibition percentage and their (estimated) response time to the stop signal was disproportionally longer compared to the slowing of reaction times to primary-task stimuli. In normal control subjects, fronto-central positivity (100-400 msec) after the onset of the stop-signal was larger in case of successful inhibition, relative to failed inhibition; this was less so in ADHDchildren. A late positive wave (500-700 msec), maximal at Oz on failed inhibition trials, and possibly related to error-detection, was smaller in ADHDchildren. CONCLUSIONS: These results point to abnormalities in brain processes involved in motor inhibition and error-detection in ADHDchildren.
Authors: Jessica N Smith; Joseph S Raiker; Whitney D Fosco; Morgan L Jusko; Mileini Campez; Kelcey Little; Aaron Mattfeld; Kisbel Espinal; Gabriela Sanchez; Brittany Merrill; Erica D Musser; Elizabeth Gnagy; Andrew Greiner; Erika Coles; William E Pelham Journal: J Abnorm Child Psychol Date: 2020-09
Authors: Andrea Burgio-Murphy; Rafael Klorman; Sally E Shaywitz; Jack M Fletcher; Karen E Marchione; John Holahan; Karla K Stuebing; Joan E Thatcher; Bennett A Shaywitz Journal: Biol Psychol Date: 2006-12-17 Impact factor: 3.251
Authors: Ayelet Lahat; Rebecca M Todd; Caitlin Emma Victoria Mahy; Karen Lau; Philip David Zelazo Journal: Front Hum Neurosci Date: 2010-01-08 Impact factor: 3.169