Literature DB >> 11950391

Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes.

Ulrike Roth1, Kurt Jungermann, Thomas Kietzmann.   

Abstract

Glucokinase (GK) is a key enzyme for glucose utilization in liver and shows a higher expression in the perivenous zone. In primary rat hepatocytes, the GK gene expression was activated by HNF (hepatic nuclear factor)-4alpha via the sequence -52/-39 of the GK promoter. Venous pO2 enhanced HNF-4 levels and HNF-4 binding to the GK-HNF-4 element. Thus, HNF-4alpha could play the role of a regulator for zonated GK expression.

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Year:  2002        PMID： 11950391      PMCID： PMC1222650          DOI： 10.1042/BJ20020340

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  50 in total

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