| Literature DB >> 11950358 |
Sanghee Kim1, Hyojin Ko, Eunkyung Kim, Deukjoon Kim.
Abstract
A new total synthesis of the antitumor alkaloids, pancratistatin (1), has been accomplished from readily available staring materials. The Claisen rearrangement of dihydropyranethylene 5 was employed to construct the A and C rings. Stereo- and regiocontrolled functional group interchange, such as iodolactonization, dihydroxylations, and a cyclic sulfate elimination reaction, allows for the production of the target natural product. [reaction: see text]Entities:
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Year: 2002 PMID： 11950358 DOI： 10.1021/ol0256419
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005