Literature DB >> 16408886

An efficient synthesis of (+/-)-Lycoricidine featuring a Stille-IMDAF cycloaddition cascade.

Hongjun Zhang1, Albert Padwa.   

Abstract

[reaction: see text] A highly efficient total synthesis of (+/-)-Lycoricidine is described. The synthesis features the ready preparation of the Lycoricidine skeleton by a Stille-IMDAF cycloaddition cascade. The resulting cycloadduct is then used for the stereocontrolled installation of the other functionality present in the C-ring of the target molecule.

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Year:  2006        PMID： 16408886      PMCID： PMC2587426          DOI： 10.1021/ol052524f

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  24 in total

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9.  Antineoplastic agents, 294. Variations in the formation of pancratistatin and related isocarbostyrils in Hymenocallis littoralis.

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  7 in total

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6.  Synthesis of some members of the hydroxylated phenanthridone subclass of the Amaryllidaceae alkaloid family.

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Journal:  J Org Chem       Date:  2007-03-06       Impact factor: 4.354

7.  Highly substituted 2-amido-furans from Rh(II)-catalyzed cyclopropenations of ynamides.

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  7 in total

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