| Literature DB >> 11950334 |
William H Dent1, W Randal Erickson, Stephen C Fields, Marshall H Parker, Eric G Tromiczak.
Abstract
9-Borabicyclononane (9-BBN) has been utilized to protect functionalized amino acids for potential chemoselective side chain manipulation. The 9-BBN group imparts organic solubility to otherwise hydrophilic molecules and is tolerant of a wide range of reaction conditions. The high degree of solubility of these molecules in THF is particularly noteworthy. It is cleaved with either aqueous HCl or by exchange with ethylenediamine in methanol. [reaction: see text]Entities:
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Year: 2002 PMID： 11950334 DOI： 10.1021/ol017241b
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005